(Q27639935)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

title

The mechanism of topoisomerase I poisoning by a camptothecin analog (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

0 references

4

1 reference

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14 December 2019

5

Alex B Burgin

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

author name string

Bart L Staker

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

Kathryn Hjerrild

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

Michael D Feese

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

Lance Stewart

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

language of work or name

English

0 references

publication date

8 November 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

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14 December 2019

volume

99

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

issue

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

page(s)

15387-15392

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

DNA topoisomerases: structure, function, and mechanism

14 December 2019

cites work

1 reference

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A model for the mechanism of human topoisomerase I

20 March 2017

1 reference

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Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

20 March 2017

1 reference

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SHELXL: high-resolution refinement

20 March 2017

1 reference

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XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

20 March 2017

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Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures

22 April 2017

1 reference

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Biochemical and biophysical analyses of recombinant forms of human topoisomerase I

20 March 2017

1 reference

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20 March 2017

1 reference

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Novel mutation of topoisomerase I in rendering cells resistant to camptothecin.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

High-throughput crystallization and structure determination in drug discovery.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

A standard reference frame for the description of nucleic acid base-pair geometry.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Tumor cell death induced by topoisomerase-targeting drugs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Modulation of camptothecin analogs in the treatment of cancer: a review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Structure-based analysis of the effects of camptothecin on the activities of human topoisomerase I.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

A-form conformational motifs in ligand-bound DNA structures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Topotecan lactone selectively binds to double- and single-stranded DNA in the absence of topoisomerase I.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Camptothecins: from bench research to hospital wards.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

DNA topoisomerases: essential enzymes and lethal targets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

A novel suicide substrate for DNA topoisomerases and site-specific recombinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Catalytic mechanism of DNA topoisomerase IB.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Kinetics of lactone hydrolysis in antitumor drugs of camptothecin series as studied by fluorescence spectroscopy.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Studies on camptothecin. I. Effects of nucleic acid and protein synthesis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Diversity of DNA topoisomerases I and inhibitors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

The effects of camptothecin on the reaction and the specificity of the wheat germ type I topoisomerase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137726

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

27 November 2018

1 reference

12 December 2020

A spectrophotometric study of the pH-dependent and DNA binding properties of topotecan

1 reference

12 December 2020

The Camptothecin-Resistant Topoisomerase I Mutant F361S Is Cross-Resistant to Antitumor Rebeccamycin Derivatives. A Model for Topoisomerase I Inhibition by Indolocarbazoles†

1 reference

12 December 2020

Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis

1 reference

12 December 2020

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

1 reference

12 December 2020

Kinetics of in vitro hydrolysis of homocamptothecins as measured by fluorescence

1 reference

12 December 2020

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin

1 reference

12 December 2020

Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.242259599

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

ADS bibcode

2002PNAS...9915387S

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12426403%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

PubMed publication ID

12426403

2 references