(Q27681720)

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Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase Inhibitors

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8 March 2020

Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors (English)

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8 March 2020

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Herwig Schüler

9

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8 March 2020

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8 March 2020

Antonio Macchiarulo

7

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8 March 2020

Emidio Camaioni

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8 March 2020

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Paride Liscio

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8 March 2020

Stefania Asciutti

3

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8 March 2020

Daniele Bellocchi

5

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8 March 2020

Laura Llacuna

6

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8 March 2020

Stuart A Aaronson

8

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8 March 2020

Roberto Pellicciari

10

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8 March 2020

Tobias Karlberg

4

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8 March 2020

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publication date

24 February 2014

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8 March 2020

Journal of Medicinal Chemistry

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8 March 2020

57

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8 March 2020

6

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8 March 2020

2807-2812

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8 March 2020

Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

20 March 2017

Fragment-based ligand design of novel potent inhibitors of tankyrases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

20 March 2017

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

20 March 2017

Structural basis of selective inhibition of human tankyrases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

20 March 2017

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

20 March 2017

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

20 March 2017

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

7 April 2017

From polypharmacology to target specificity: the case of PARP inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

29 September 2017

Tankyrases as drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

29 September 2017

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

29 September 2017

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

29 September 2017

Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4406096

2 June 2018

Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/24527792

12 December 2020

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10.1021/JM401356T

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8 March 2020

1 reference

Europe PubMed Central

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8 March 2020

1 reference

Europe PubMed Central

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8 March 2020

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