(Q38063790)

28 August 2017

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title

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family (English)

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28 August 2017

2

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28 August 2017

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Alan Ashworth

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28 August 2017

1

Jenna L Riffell

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28 August 2017

publication date

1 December 2012

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Nature Reviews Drug Discovery

28 August 2017

published in

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28 August 2017

volume

11

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28 August 2017

issue

12

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28 August 2017

page(s)

923-936

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(ADP-ribose)n participates in DNA excision repair

28 August 2017

cites work

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The Effect of Inhibition of (ADP‐ribose)n Biosynthesis on DNA Repair Assayed by the Nucleoid Technique

31 March 2020

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PARP inhibition: PARP1 and beyond

31 March 2020

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Novel inhibitors of poly(ADP-ribose) synthetase

31 March 2020

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Inhibition of (ADP-ribose)n biosynthesis retards DNA repair but does not inhibit DNA repair synthesis

31 March 2020

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

31 March 2020

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

31 March 2020

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Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

31 March 2020

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Tankyrase function at telomeres, spindle poles, and beyond.

31 March 2020

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TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

31 March 2020

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Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

31 March 2020

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Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

31 March 2020

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Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation

31 March 2020

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Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

31 March 2020

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The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)

31 March 2020

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Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles

31 March 2020

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Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3

31 March 2020

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Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation

31 March 2020

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PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation

31 March 2020

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Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition

31 March 2020

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A DNA damage checkpoint response in telomere-initiated senescence

31 March 2020

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

31 March 2020

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Is telomerase a viable target in cancer?

31 March 2020

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Regulation of telomerase by telomeric proteins

31 March 2020

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How shelterin protects mammalian telomeres

31 March 2020

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Tankyrase promotes telomere elongation in human cells

31 March 2020

2 references

31 March 2020

12 December 2020

The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance

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Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.

31 March 2020

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The kinase activity of DNA-PK is required to protect mammalian telomeres

31 March 2020

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Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence

31 March 2020

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Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs

31 March 2020

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The role of the poly(ADP-ribose) polymerase tankyrase1 in telomere length control by the TRF1 component of the shelterin complex

31 March 2020

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31 March 2020

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Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.

31 March 2020

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High-throughput RNAi screening reveals novel regulators of telomerase

31 March 2020

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Wnt/β-catenin signaling and disease

31 March 2020

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A member of the Frizzled protein family mediating axis induction by Wnt-5A

31 March 2020

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31 March 2020

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

31 March 2020

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Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex

31 March 2020

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

31 March 2020

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RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

31 March 2020

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Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling

31 March 2020

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Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase

31 March 2020

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Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

31 March 2020

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β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

31 March 2020

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Cardiac Induction of Embryonic Stem Cells by a Small Molecule Inhibitor of Wnt/β-Catenin Signaling

31 March 2020

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Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis

31 March 2020

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Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

31 March 2020

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Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ

31 March 2020

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Resolution of sister telomere association is required for progression through mitosis

31 March 2020

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NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.

31 March 2020

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Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

31 March 2020

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Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

31 March 2020

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CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10).

31 March 2020

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Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase

31 March 2020

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The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation

31 March 2020

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Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism

31 March 2020

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Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1.

31 March 2020

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Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

31 March 2020

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Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2

31 March 2020

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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

31 March 2020

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A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

31 March 2020

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A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor

31 March 2020

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Structural basis of selective inhibition of human tankyrases

31 March 2020

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Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor

31 March 2020

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[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding

31 March 2020

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Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

31 March 2020

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PARP inhibitor development for systemic cancer targeting

31 March 2020

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Cross-species difference in telomeric function of tankyrase 1.

31 March 2020

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Biology-driven cancer drug development: back to the future

31 March 2020

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

31 March 2020

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Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

31 March 2020

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Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

31 March 2020

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

31 March 2020

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Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

31 March 2020

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Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase

31 March 2020

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Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells

31 March 2020

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PARP-3 and APLF function together to accelerate nonhomologous end-joining

31 March 2020

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The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase

31 March 2020

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MVP and vaults: a role in the radiation response

31 March 2020

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Complex roles of members of the ADP-ribosyl transferase super family in immune defences: looking beyond PARP1.

31 March 2020

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Involvement of poly(ADP-ribose) polymerase in base excision repair

31 March 2020

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Base-excision repair of oxidative DNA damage

31 March 2020

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

31 March 2020

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

31 March 2020

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The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art.

31 March 2020

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Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer

31 March 2020

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Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.

31 March 2020

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Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture

31 March 2020

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Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro

31 March 2020

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Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.

31 March 2020

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Role of poly(ADP-ribose) glycohydrolase in the regulation of cell fate in response to benzo(a)pyrene

31 March 2020

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Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase

31 March 2020

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PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.

31 March 2020

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Radiation-induced mitotic catastrophe in PARG-deficient cells.

31 March 2020

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Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells

31 March 2020

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Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).

31 March 2020

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GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity.

31 March 2020

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4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

31 March 2020

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Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors

31 March 2020

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The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity

31 March 2020

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31 March 2020

Wnt signaling and cancer

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12 December 2020

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.

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12 December 2020

BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway

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12 December 2020

Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei

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12 December 2020

Identifiers

DOI

10.1038/NRD3868

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28 August 2017

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