(Q27682804)

6

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author name string

Siobhan Hughes

1

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Frédéric Elustondo

2

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Andrea Di Fonzo

3

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Frédéric G Leroux

4

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Ai C Wong

5

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Stephen J Matthews

Nature Structural & Molecular Biology

7

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language of work or name

1 reference

November 2012

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published in

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volume

19

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issue

11

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page(s)

1101-7

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cites work

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Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

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CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein

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Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin

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Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation

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Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7

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Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination

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The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

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Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity

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