(Q27683486)

English

A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV

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A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV (English)

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Ravikiran S Yedidi

1

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31 May 2020

Paul T. Wingfield

12

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31 May 2020

13

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31 May 2020

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Harisha Garimella

2

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31 May 2020

Manabu Aoki

3

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31 May 2020

Hiromi Aoki-Ogata

4

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31 May 2020

Darshan V Desai

5

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31 May 2020

Simon B Chang

6

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31 May 2020

David A Davis

7

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31 May 2020

W Sean Fyvie

8

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31 May 2020

Joshua D Kaufman

9

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31 May 2020

David W Smith

10

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31 May 2020

Debananda Das

11

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31 May 2020

Arun K Ghosh

14

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31 May 2020

Hiroaki Mitsuya

15

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31 May 2020

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July 2014

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Antimicrobial Agents and Chemotherapy

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31 May 2020

58

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31 May 2020

7

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31 May 2020

3679-3688

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31 May 2020

P2' Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety

1 reference

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20 March 2017

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants

1 reference

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20 March 2017

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

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20 March 2017

Unique Thermodynamic Response of Tipranavir to Human Immunodeficiency Virus Type 1 Protease Drug Resistance Mutations

1 reference

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20 March 2017

Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization

1 reference

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20 March 2017

Active human immunodeficiency virus protease is required for viral infectivity

1 reference

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20 March 2017

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20 March 2017

BALBES: a molecular-replacement pipeline

1 reference

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20 March 2017

Scaling and assessment of data quality

1 reference

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20 March 2017

The integration of macromolecular diffraction data

1 reference

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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20 March 2017

Automated refinement of protein models

1 reference

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20 March 2017

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

1 reference

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20 March 2017

A graphical user interface to the CCP4 program suite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068604

20 March 2017

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068604

20 March 2017

Solvent content of protein crystals

1 reference

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20 March 2017

A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068604

20 March 2017

electronic Ligand Builder and Optimization Workbench (eLBOW): a tool for ligand coordinate and restraint generation

1 reference

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7 April 2017

Enhancing protein backbone binding--a fruitful concept for combating drug-resistant HIV.

1 reference

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29 September 2017

In vitro selection of highly darunavir-resistant and replication-competent HIV-1 variants by using a mixture of clinical HIV-1 isolates resistant to multiple conventional protease inhibitors.

1 reference

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29 September 2017

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

1 reference

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29 September 2017

Prevalence of darunavir resistance-associated mutations: patterns of occurrence and association with past treatment

1 reference

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29 September 2017

HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance

1 reference

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29 September 2017

Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease.

1 reference

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29 September 2017

Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

1 reference

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29 September 2017

JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.

1 reference

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29 September 2017

Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1.

1 reference

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29 September 2017

Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068604

29 September 2017

Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity.

1 reference

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29 September 2017

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1 reference

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1 reference

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27 November 2018

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1 reference

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27 November 2018

Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease

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1 reference

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12 December 2020

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10.1128/AAC.00107-14

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31 May 2020

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31 May 2020

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31 May 2020

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