(Q27683750)

1

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Caroline Haase

2

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Maya Hammami

3

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Torsten Steinmetzer

The molecular biology of West Nile Virus: a new invader of the western hemisphere

5

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publication date

February 2013

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published in

ChemMedChem

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volume

8

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issue

2

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page(s)

231-41

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cites work

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Globalization, land use, and the invasion of West Nile virus

21 January 2018

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Immunopathology of flavivirus infections

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Replication strategy of Kunjin virus: evidence for recycling role of replicative form RNA as template in semiconservative and asymmetric replication

21 January 2018

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Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus

21 January 2018

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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

21 January 2018

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Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies

21 January 2018

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West Nile Virus NS2B/NS3 protease as an antiviral target

21 January 2018

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Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase

21 January 2018

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Small molecule pan-dengue and West Nile virus NS3 protease inhibitors

21 January 2018

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Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors

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Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.

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Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput Screen

21 January 2018

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Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease.

21 January 2018

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Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

21 January 2018

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Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors

21 January 2018

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Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity

21 January 2018

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Tripeptide inhibitors of dengue and West Nile virus NS2B-NS3 protease

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Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold

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Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation

21 January 2018

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Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents

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A new strategy for the development of highly potent and selective plasmin inhibitors

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Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics

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Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease

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A new oral anticoagulant: the 50-year challenge

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Type II transmembrane serine proteases in development and disease

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Matriptase: a culprit in cancer?

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Features and development of Coot

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More hydrogen bonds for the (structural) biologist.

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Protease inhibitors in the clinic.

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Halogen bonds in biological molecules

21 January 2018

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Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect

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Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases

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Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B–NS3 junction region

21 January 2018

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Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin

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Scaling and assessment of data quality

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Overview of the CCP4 suite and current developments

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Phasercrystallographic software

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Solvent content of protein crystals

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

21 January 2018

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Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

21 January 2018

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The determination of enzyme inhibitor constants

21 January 2018

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Effects of detergents on the West Nile virus protease activity

21 January 2018

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Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase

21 January 2018

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7 January 2021

Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor

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7 January 2021

Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site

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7 January 2021

Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position

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7 January 2021

C-H...pi-interactions in proteins

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7 January 2021

New substrate analogue inhibitors of factor Xa containing 4-amidinobenzylamide as P1 residue: part 1

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7 January 2021

On the use of the merging R factor as a quality indicator for X-ray data

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7 January 2021

Global indicators of X-ray data quality

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7 January 2021

Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine

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7 January 2021