(Q44901198)

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Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents

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scholarly article

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Europe PubMed Central

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7 December 2017

Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

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based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

Jörg Stürzebecher

12

object named as

Jörg Stürzebecher

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Anne Stürzebecher

5

object named as

Anne Stürzebecher

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Europe PubMed Central

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7 December 2017

Andrea Schweinitz

1

object named as

Andrea Schweinitz

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7 December 2017

author name string

Torsten Steinmetzer

2

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7 December 2017

Ingo J Banke

3

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Europe PubMed Central

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7 December 2017

Matthias J E Arlt

4

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7 December 2017

Oliver Schuster

6

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7 December 2017

Andreas Geissler

7

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Europe PubMed Central

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7 December 2017

Helmut Giersiefen

8

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7 December 2017

Ewa Zeslawska

9

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7 December 2017

Uwe Jacob

10

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7 December 2017

Achim Krüger

11

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7 December 2017

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publication date

18 May 2004

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7 December 2017

Journal of Biological Chemistry

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7 December 2017

279

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7 December 2017

32

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7 December 2017

33613-33622

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Europe PubMed Central

PubMed publication ID

7 December 2017

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

The plasminogen activation system in tumor growth, invasion, and metastasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Inhibitors of the protease domain of urokinase-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

3-Amidinophenylalanine-based inhibitors of urokinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Influence of structural variations in peptidomimetic 4-amidinophenylalanine-derived thrombin inhibitors on plasma clearance and biliary excretion in rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Species specificity of amidine-based urokinase inhibitors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Advances in the development of thrombin inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Restart procedures for the conjugate gradient method

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Clonidine displacement from type 1 imidazoline receptor by p-aminobenzamidine, the prototype of trypsin-like serine protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Clinical utility of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 determination in primary breast cancer tissue for individualized therapy concepts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins

1 reference

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21 January 2018

Peptide-derived antagonists of the urokinase receptor. affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Both u-PA inhibition and vitronectin binding by plasminogen activator inhibitor 1 regulate HT1080 fibrosarcoma cell metastasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Intravenous anesthetic, propofol inhibits invasion of cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Growth stimulation of human epidermal cells by urokinase is restricted to the intact active enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314151200

21 January 2018

Differential effects of transforming growth factor-β1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M314151200

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

ResearchGate publication ID

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