(Q27684844)

3

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André Mitschler

4

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Jean-Louis Mandel

7

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Yvon Trottier

object named as

Yvon Trottier

9

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Gabrielle Zeder-Lutz

2

object named as

Gabrielle Zeder-Lutz

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author name string

Fabrice A C Klein

1

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Aline Katz

5

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Pascal Eberling

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

6

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publication date

15 October 2013

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published in

Human Molecular Genetics

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volume

22

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issue

20

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page(s)

4215-23

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cites work

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Glutamine repeats and inherited neurodegenerative diseases: molecular aspects

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Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

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A linear lattice model for polyglutamine in CAG-expansion diseases

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Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

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Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions.

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Explaining the length threshold of polyglutamine aggregation

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Solution structure of polyglutamine tracts in GST-polyglutamine fusion proteins

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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

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New model for crystalline polyglutamine assemblies and their connection with amyloid fibrils

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Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

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Identifying polyglutamine protein species in situ that best predict neurodegeneration

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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Single homopolypeptide chains collapse into mechanically rigid conformations

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