(Q27698300)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25760601%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP (English)

1 reference

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2 March 2020

4

1 reference

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2 March 2020

author name string

Chun Feng Zhu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25760601%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Wei Wei

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25760601%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Xin Peng

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25760601%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Yong Gong

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25760601%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Xiao Fang Yu

6

1 reference

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2 March 2020

publication date

26 February 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25760601%20AND%20SRC:MED&resulttype=core&format=json

Acta Crystallographica Section D: Biological Crystallography

2 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25760601%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

71

1 reference

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2 March 2020

issue

Pt 3

1 reference

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2 March 2020

page(s)

516-524

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

2 March 2020

cites work

1 reference

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HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

21 January 2018

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GTP is the primary activator of the anti-HIV restriction factor SAMHD1.

21 January 2018

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Restricting HIV the SAMHD1 way: through nucleotide starvation.

21 January 2018

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SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

21 January 2018

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SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

21 January 2018

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Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.

21 January 2018

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Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac

21 January 2018

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SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

21 January 2018

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SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells

21 January 2018

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Coot: model-building tools for molecular graphics

21 January 2018

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Accurate bond and angle parameters for X-ray protein structure refinement

21 January 2018

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The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

21 January 2018

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The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents

21 January 2018

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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

21 January 2018

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GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

21 January 2018

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Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2.

21 January 2018

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The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus

21 January 2018

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Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

21 January 2018

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

21 January 2018

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Structural basis of cellular dNTP regulation by SAMHD1.

21 January 2018

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Mechanism of allosteric activation of SAMHD1 by dGTP

21 January 2018

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SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

21 January 2018

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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

21 January 2018

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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

21 January 2018

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Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

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REFMAC5 for the refinement of macromolecular crystal structures

21 January 2018

1 reference

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714027527

Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

21 January 2018

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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

21 January 2018

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The SAMHD1 knockout mouse model: in vivo veritas?

21 January 2018

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Structural basis of lentiviral subversion of a cellular protein degradation pathway

21 January 2018

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Molecular replacement with MOLREP

21 January 2018

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A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest

21 January 2018

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Overview of the CCP4 suite and current developments

21 January 2018

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Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection

21 January 2018

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A naturally immunogenic virion-associated protein specific for HIV-2 and SIV.

21 January 2018

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Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.

21 January 2018

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10.1107/S1399004714027527

21 January 2018

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25760601%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017