(Q55056626)

16 June 2018

title

Restricting HIV the SAMHD1 way: through nucleotide starvation. (English)

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16 June 2018

Olivier Schwartz

3

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author name string

Diana Ayinde

series ordinal

1

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16 June 2018

Nicoletta Casartelli

series ordinal

2

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16 June 2018

language of work or name

English

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publication date

28 August 2012

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16 June 2018

Nature Reviews Microbiology

published in

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16 June 2018

volume

10

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16 June 2018

issue

10

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16 June 2018

page(s)

675-680

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16 June 2018

https://scigraph.springernature.com/pub.10.1038/nrmicro2862

exact match

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cites work

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Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion

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21 January 2018

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21 January 2018

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The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection

21 January 2018

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SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells

21 January 2018

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A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection

21 January 2018

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21 January 2018

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21 January 2018

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

The many faces of SAM

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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

21 January 2018

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HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

21 January 2018

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21 January 2018

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21 January 2018

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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

21 January 2018

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Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells

21 January 2018

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SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

21 January 2018

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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

21 January 2018

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Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages

21 January 2018

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Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase

21 January 2018

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21 January 2018

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Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

21 January 2018

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Exploiting drug repositioning for discovery of a novel HIV combination therapy

21 January 2018

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Diminished human immunodeficiency virus type 1 reverse transcription and nuclear transport in primary macrophages arrested in early G(1) phase of the cell cycle

21 January 2018

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Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication

21 January 2018

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks

21 January 2018

1 reference

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High efficiency lentiviral gene delivery in non-dividing cells by deoxynucleoside treatment

21 January 2018

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Quiescent T cells and HIV: an unresolved relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Mechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Modification of human immunodeficiency virus type 1 reverse transcriptase to target cells with elevated cellular dNTP concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Ribonucleotide reductase encoded by herpes simplex virus is a determinant of the pathogenicity of the virus in mice and a valid antiviral target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

HIV-2: the forgotten AIDS virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Innate sensing of HIV-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Automated genome-wide visual profiling of cellular proteins involved in HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Gene acquisition in HIV and SIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Origin of vpx in lentiviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO2862

Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursors

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22926205

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Progression to AIDS in the absence of a gene for vpr or vpx.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22926205

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nonproductive human immunodeficiency virus type 1 infection in nucleoside-treated G0 lymphocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22926205

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRMICRO2862

1 reference

16 June 2018

Dimensions Publication ID

0 references

1 reference

16 June 2018