(Q27700205)

6

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Gerhard Wolber

object named as

Gerhard Wolber

7

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Jörg Rademann

object named as

Jörg Rademann

10

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author name string

Stefanie Grosskopf

1

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Chris Eckert

2

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Christoph Arkona

3

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Silke Radetzki

4

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Kerstin Böhm

5

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Jens-Peter von Kries

8

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Walter Birchmeier

Challenges and opportunities in the development of protein phosphatase-directed therapeutics.

9

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publication date

May 2015

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published in

ChemMedChem

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volume

10

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issue

5

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page(s)

815-26

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cites work

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Crystal structure of the tyrosine phosphatase SHP-2

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How to make tubes: signaling by the Met receptor tyrosine kinase

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Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

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SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein

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Helicobacter pylori activates mitogen-activated protein kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun.

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

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Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

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Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases.

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Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors

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Facilities and methods for the high-throughput crystal structural analysis of human proteins.

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Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

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ARP/wARP and molecular replacement

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Coot: model-building tools for molecular graphics

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Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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Errors in protein structures

21 January 2018

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SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

21 January 2018

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LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

21 January 2018

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Efficient overlay of small organic molecules using 3D pharmacophores

21 January 2018

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Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

21 January 2018

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Effect of scatter factor on motility of epithelial cells and fibroblasts

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inferred from DOI database lookup

7 January 2021

based on heuristic

Strategies for 3D pharmacophore-based virtual screening

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inferred from DOI database lookup

7 January 2021

based on heuristic

Improved detection of drug cytotoxicity in the soft agar colony formation assay through use of a metabolizable tetrazolium salt

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