(Q27701731)

Aryl hydrocarbon receptor nuclear translocator

GOA release 2020-03-11

1 reference

Hypoxia inducible factor 1, alpha subunit

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Dalei Wu

1

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Nalini Potluri

2

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Jingping Lu

3

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Youngchang Kim

4

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Fraydoon Rastinejad

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

5

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language of work or name

English

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publication date

20 August 2015

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published in

Nature

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volume

524

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issue

7565

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page(s)

303-8

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cites work

1 reference

12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

12 December 2020

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

1 reference

12 December 2020

Features and development of Coot

1 reference

12 December 2020

Molecular basis of the VHL hereditary cancer syndrome

1 reference

12 December 2020

Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules

1 reference

12 December 2020

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

1 reference

12 December 2020

Structure and signaling mechanism of Per-ARNT-Sim domains

1 reference

12 December 2020

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

12 December 2020

Phasercrystallographic software

1 reference

12 December 2020

MolProbity: all-atom structure validation for macromolecular crystallography

1 reference

12 December 2020

Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor

1 reference

12 December 2020

Ligand-binding PAS domains in a genomic, cellular, and structural context

1 reference

12 December 2020

Mammalian Per-Arnt-Sim proteins in environmental adaptation

1 reference

12 December 2020

Hypoxia-inducible factors in physiology and medicine

1 reference

12 December 2020

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

1 reference

12 December 2020

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 December 2020

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

1 reference

12 December 2020

Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor PAS-A Domain

1 reference

12 December 2020

Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA

1 reference

12 December 2020

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

1 reference

12 December 2020

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

12 December 2020

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

1 reference

12 December 2020

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

1 reference

12 December 2020

bHLH-PAS proteins in cancer

1 reference

12 December 2020

Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor

1 reference

12 December 2020

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization

1 reference

12 December 2020

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

1 reference

12 December 2020

Aryl hydrocarbon receptor ligands in cancer: friend and foe.

1 reference

12 December 2020

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

12 December 2020

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.

1 reference

12 December 2020

Hypoxia--a key regulatory factor in tumour growth

1 reference

12 December 2020

Deciphering key features in protein structures with the new ENDscript server

1 reference

12 December 2020

Integrated molecular analysis of clear-cell renal cell carcinoma

1 reference

12 December 2020

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

12 December 2020

Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype

1 reference

12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 December 2020

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

1 reference

12 December 2020

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

1 reference

12 December 2020

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

12 December 2020

HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

1 reference

12 December 2020

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene

1 reference

12 December 2020

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

1 reference

12 December 2020

Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor

1 reference

12 December 2020

Principles of Ligand Binding within a Completely Buried Cavity in HIF2α PAS-B

1 reference

12 December 2020

Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.

1 reference

12 December 2020

Hypoxia-inducible factor 1 and cardiovascular disease

1 reference

12 December 2020

Novel links between HIFs, type 2 diabetes, and metabolic syndrome

1 reference

12 December 2020

The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology

1 reference

12 December 2020

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction

1 reference

12 December 2020

Integration of oxygen signaling at the consensus HRE.

1 reference

12 December 2020

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

1 reference

12 December 2020

The transcriptional landscape and mutational profile of lung adenocarcinoma.

1 reference

12 December 2020

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

12 December 2020

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma

1 reference

12 December 2020

The PDB_REDO server for macromolecular structure model optimization

1 reference

12 December 2020

Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma

1 reference

12 December 2020

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

1 reference

12 December 2020

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 December 2020

Clustal W and Clustal X version 2.0

1 reference

12 December 2020

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

1 reference

12 December 2020

NPAS2: a gas-responsive transcription factor

1 reference

12 December 2020

The mammalian basic helix-loop-helix/PAS family of transcriptional regulators

1 reference

12 December 2020

The HIF pathway as a therapeutic target

1 reference

12 December 2020