(Q27701867)

1

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Jing Hang

2

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Ruixue Wan

3

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Min Huang

4

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Catherine C L Wong

Spliceosome Structure and Function

5

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language of work or name

English

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publication date

11 September 2015

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published in

Science

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volume

349

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issue

6253

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page(s)

1182-91

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cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

The spliceosome: design principles of a dynamic RNP machine

21 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Dynamic protein-protein interaction wiring of the human spliceosome

21 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Mechanical devices of the spliceosome: motors, clocks, springs, and things

21 April 2017

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https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

A general two-metal-ion mechanism for catalytic RNA

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Functional organization of the Sm core in the crystal structure of human U1 snRNP

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Structure of the 30S ribosomal subunit

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Molecular architecture of the human Prp19/CDC5L complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Prp8 protein: at the heart of the spliceosome

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Structure and assembly of the SF3a splicing factor complex of U2 snRNP

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

EMAN2: an extensible image processing suite for electron microscopy

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Accurate determination of local defocus and specimen tilt in electron microscopy

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

UCSF Chimera--a visualization system for exploratory research and analysis

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

The CCP4 suite: programs for protein crystallography

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Coot: model-building tools for molecular graphics

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Refinement of macromolecular structures by the maximum-likelihood method

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.AAC7629

RELION: implementation of a Bayesian approach to cryo-EM structure determination

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

The spliceosome: disorder and dynamics defined

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Structure, function and regulation of spliceosomal RNA helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Crystal structure of Prp8 reveals active site cavity of the spliceosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Structural studies of the spliceosome: zooming into the heart of the machine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Three-dimensional structure of the native spliceosome by cryo-electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Three-dimensional structure of a pre-catalytic human spliceosomal complex B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Three-dimensional structure of C complex spliceosomes by electron microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Structural characterization of the fission yeast U5.U2/U6 spliceosome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Exon, intron and splice site locations in the spliceosomal B complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Rearrangements within human spliceosomes captured after exon ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Purification and electron microscopic visualization of functional human spliceosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Structural basis of pre-mRNA splicing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

The HAT helix, a repetitive motif implicated in RNA processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Intrinsic disorder in the human spliceosomal proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Splicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Saccharomyces cerevisiae NineTeen complex (NTC)-associated factor Bud31/Ycr063w assembles on precatalytic spliceosomes and improves first and second step pre-mRNA splicing efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Homozygous splice mutation in CWF19L1 in a Turkish family with recessive ataxia syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Structural basis for polypyrimidine tract recognition by the essential pre-mRNA splicing factor U2AF65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Structural mapping of spliceosomes by electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Vectors and gene targeting modules for tandem affinity purification in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Beam-induced motion correction for sub-megadalton cryo-EM particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Quantifying the local resolution of cryo-EM density maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629

Metal ion catalysis during splicing of premessenger RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC7629