(Q27704850)

English

Structural plasticity broadens the specificity of an engineered protease

scientific article

In more languages

Statements

scholarly article

0 references

Structural plasticity broadens the specificity of an engineered protease (English)

0 references

author name string

R Bone

1

0 references

J L Silen

2

0 references

D A Agard

3

0 references

language of work or name

0 references

publication date

18 May 1989

0 references

0 references

339

0 references

6221

0 references

191-5

0 references

Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

A specific, highly active malate dehydrogenase by redesign of a lactate dehydrogenase framework

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Redesigning trypsin: alteration of substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of arginine-292 in the substrate specificity of aspartate aminotransferase as examined by site-directed mutagenesis.

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular structure of the α-lytic protease from Myxobacter 495 at 2·8 Å resolution

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of action of serine proteases: tetrahedral intermediate and concerted proton transfer

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Catalytic mechanism of serine proteases: reexamination of the pH dependence of the histidyl 1J13C2-H coupling constant in the catalytic triad of alpha-lytic protease

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

High resolution nuclear magnetic resonance studies of the active site of chymotrypsin. II. Polarization of histidine 57 by substrate analogues and competitive inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Active site of alpha-lytic protease: enzyme-substrate interactions

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

The influence of the geometric properties of the active centre on the specificity of α‐chymotrypsin catalysis

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester s

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Analytical molecular surface calculation

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Solvent-accessible surfaces of proteins and nucleic acids

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Carbon nuclear magnetic resonance studies of the histidine residue in alpha-lytic protease. Implications for the catalytic mechanism of serine proteases.

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

17 The kinetics of reversible tight-binding inhibition

1 reference

https://api.crossref.org/works/10.1038%2F339191A0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/339191A0

0 references

Dimensions Publication ID

0 references

PubMed publication ID

0 references

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q27704850&oldid=2175344717"