(Q27721834)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27454931%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition (English)

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19 March 2020

1

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19 March 2020

author name string

Jeremy J Keusch

2

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19 March 2020

Longlong Wang

3

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19 March 2020

Makoto Saito

4

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19 March 2020

Daniel Hess

5

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19 March 2020

Xiaoning Wang

6

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19 March 2020

Bruce J Melancon

7

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19 March 2020

Paul Helquist

8

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19 March 2020

Heinz Gut

9

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19 March 2020

Patrick Matthias

10

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19 March 2020

publication date

25 July 2016

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19 March 2020

published in

Nature Chemical Biology

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19 March 2020

volume

12

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19 March 2020

issue

9

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19 March 2020

page(s)

748-754

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HDAC6 is a microtubule-associated deacetylase

19 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

The role of HDAC6 in cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Crystal Structures of Tubulin Acetyltransferase Reveal a Conserved Catalytic Core and the Plasticity of the Essential N Terminus

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors † , ‡

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Data processing and analysis with the autoPROC toolbox

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Phasercrystallographic software

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

The Buccaneer software for automated model building. 1. Tracing protein chains

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Towards automated crystallographic structure refinement with phenix.refine

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Features and development of Coot

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

The HHpred interactive server for protein homology detection and structure prediction

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

Comparative protein structure modeling of genes and genomes

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.2140

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Acetylation site specificities of lysine deacetylase inhibitors in human cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

HDAC6 modulates cell motility by altering the acetylation level of cortactin

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Influenza A virus uses the aggresome processing machinery for host cell entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Histone deacetylase 6 in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Microtubules: greater than the sum of the parts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Writing and Reading the Tubulin Code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

High-resolution model of the microtubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Characterization of the two catalytic domains in histone deacetylase 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Two catalytic domains are required for protein deacetylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Histone deacetylase inhibitors: structure-based modeling and isoform-selectivity prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

In vitro microtubule severing assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

A novel method for purification of polymerizable tubulin with a high content of the acetylated isotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2140

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A

21 January 2018

1 reference

12 December 2020

Histone deacetylase 6 (HDAC6) is an independent deacetylase for alpha-tubulin

1 reference

12 December 2020

Dynamics of alpha-tubulin deacetylation in intact neurons

1 reference

12 December 2020

Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells

1 reference

12 December 2020

Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.2140

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27454931%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 March 2020

1025396733

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017