(Q27731513)

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Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase

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title

Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase (English)

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2

E E Howell

E E

Howell

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20 October 2023

K A Brown

1

K A

Brown

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20 October 2023

J Kraut

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3

author given names

J

author last names

Kraut

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20 October 2023

language of work or name

English

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publication date

15 December 1993

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published in

Proceedings of the National Academy of Sciences of the United States of America

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volume

90

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page(s)

11753-6

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issue

24

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cites work

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate

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PubMed Central

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Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state

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PubMed Central

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20 March 2017

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

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7 April 2017

Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis

1 reference

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PubMed Central

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29 September 2017

Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft

1 reference

stated in

PubMed Central

reference URL

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29 September 2017

Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate

1 reference

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PubMed Central

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29 September 2017

Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis.

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2 June 2018

Mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli: pH and deuterium isotope effects with NADPH as the variable substrate

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PubMed Central

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2 June 2018

Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase

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2 June 2018

The alpha subunit of tryptophan synthase. Evidence that aspartic acid 60 is a catalytic residue and that the double alteration of residues 175 and 211 in a second-site revertant restores the proper geometry of the substrate binding site.

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2 June 2018

A second-site mutation at phenylalanine-137 that increases catalytic efficiency in the mutant aspartate-27----serine Escherichia coli dihydrofolate reductase.

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2 June 2018

Structure and function of alternative proton-relay mutants of dihydrofolate reductase

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2 June 2018

Structure of a ricin mutant showing rescue of activity by a noncatalytic residue

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Kinetic analysis of the mechanism of Escherichia coli dihydrofolate reductase.

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19 June 2018

Some structural and photochemical properties of Rhodopseudomonas palustris subchromatophore particles obtained by treatment with Triton X-100

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PubMed

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retrieved

12 December 2020

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inferred from PubMed ID database lookup

Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihydrofolate reductase by side-chain interchange

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8265622

retrieved

12 December 2020

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Identifiers

DOI

10.1073/PNAS.90.24.11753

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ADS bibcode

1993PNAS...9011753B

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Fatcat ID

release_qddjqwbbnze7xdftaapl6e7b7q

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https://api.fatcat.wiki/v0/release/qddjqwbbnze7xdftaapl6e7b7q

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24 November 2022

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ResearchGate publication ID

14932915

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(Q27731513)

Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase

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