(Q27739575)

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A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil

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A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil (English)

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crystal structure

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1 reference

ChEBI release 2020-05-28

author name string

A Urzhumtsev

1

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F Tête-Favier

2

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A Mitschler

3

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J Barbanton

4

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P Barth

5

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L Urzhumtseva

6

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J F Biellmann

7

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A Podjarny

8

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D Moras

9

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publication date

15 May 1997

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5

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5

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601-12

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Medicinal chemistry of aldose reductase inhibitors

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Properties of an aldose reductase from pig lens. Comparative studies of an aldehyde reductase from pig lens

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An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications

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Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil

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N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor

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(2,6-Dimethylphenylsulphonyl)nitromethane: a new structural type of aldose reductase inhibitor which follows biphasic kinetics and uses an allosteric binding site

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Kinetic and spectroscopic evidence for active site inhibition of human aldose reductase

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10.1016/S0969-2126(97)00216-5

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