(Q27824787)

13 November 2016

title

Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor (English)

1 reference

PubMed

PubMed publication ID

13 November 2016

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K-F Tse

1

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J Allebach

2

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M Levis

3

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B D Smith

4

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F D Bohmer

5

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D Small

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

6

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publication date

October 2002

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published in

Leukemia

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volume

16

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issue

10

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page(s)

2027-36

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Expression of Flt3-ligand by the endothelial cell

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021

Differential function of STAT5 isoforms in head and neck cancer growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402674

7 January 2021