(Q27851556)

13 November 2016

title

Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts (English)

1 reference

PubMed

PubMed publication ID

13 November 2016

1 reference

1 reference

1 reference

6

Michael D Prados

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author name string

Karine Michaud

1

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David A Solomon

2

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Eric Oermann

3

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Jung-Sik Kim

4

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Wei-Zhu Zhong

5

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Tomoko Ozawa

7

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C David James

8

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Todd Waldman

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

9

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language of work or name

English

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publication date

15 April 2010

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published in

Cancer Research

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volume

70

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issue

8

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page(s)

3228-38

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cites work

1 reference

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Cell cycle, CDKs and cancer: a changing paradigm

20 March 2017

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

20 March 2017

1 reference

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An integrated genomic analysis of human glioblastoma multiforme

20 March 2017

1 reference

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Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development

20 March 2017

1 reference

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

20 March 2017

1 reference

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Cell cycle kinases as therapeutic targets for cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Deletion of p16 and p15 genes in brain tumors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma

20 March 2017

1 reference

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Sample type bias in the analysis of cancer genomes

29 September 2017

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Temozolomide in malignant gliomas: current use and future targets

29 September 2017

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Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts

29 September 2017

1 reference

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Advancing bioluminescence imaging technology for the evaluation of anticancer agents in the MDA-MB-435-HAL-Luc mammary fat pad and subrenal capsule tumor models

29 September 2017

1 reference

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Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Radiotherapy and radiosensitizers in the treatment of glioblastoma multiforme.

29 September 2017

1 reference

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Influence of in vivo growth on human glioma cell line gene expression: convergent profiles under orthotopic conditions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Treatment of growing teratoma syndrome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2855904

CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20354191

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-09-4559

1 reference

1 reference

1 reference

PubMed publication ID

20354191

1 reference