(Q28079028)

English

Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

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scholarly article

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Europe PubMed Central

Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases (English)

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G protein-coupled receptor

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author name string

Hariharan Subramanian

1

1 reference

Kshitij Gupta

2

1 reference

Hydar Ali

3

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language of work or name

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publication date

September 2016

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The Journal of Allergy and Clinical Immunology

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138

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3

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700-10

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Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

1 reference

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Innate immunity and its regulation by mast cells

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Developmental origin and functional specialization of mast cell subsets

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Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization

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Anaphylatoxin C3a receptors in asthma

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β-Defensins activate human mast cells via Mas-related gene X2.

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G protein-dependent activation of mast cell by peptides and basic secretagogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Regulation of mast cell-mediated innate immunity during early response to bacterial infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Defensins of vertebrate animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Innate antimicrobial peptide protects the skin from invasive bacterial infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Human mast cell and airway smooth muscle cell interactions: implications for asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Different patterns of mast cell activation by muscle relaxants in human skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Mast cells as sentinels of innate immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Mechanism of peptide-induced mast cell degranulation. Translocation and patch-clamp studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Serum levels of substance P are elevated in patients with sickle cell disease and increase further during vaso-occlusive crisis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Interaction of neurotensin with the substance P receptor mediating histamine release from rat mast cells and the flare in human skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Mast cell/nerve interactions in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Substance P and beta-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

29 September 2017

Mast cell activation contributes to sickle cell pathobiology and pain in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

The role of respiratory viruses in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Membrane-assisted molecular mechanism of neurokinin receptor subtype selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Association between histamine-containing mast cells and sensory nerves in the skin and airways of control and capsaicin-treated pigs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Interaction of substance P, compound 4880 and mastoparan with the α-subunit C-terminus of G protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

2 June 2018

Human-derived cathelicidin LL-37 directly activates mast cells to proinflammatory mediator synthesis and migratory response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Establishment of a human allergy model using human IL-3/GM-CSF-transgenic NOG mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Activation of human mast cells through the platelet-activating factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Mast cell–driven skin inflammation is impaired in the absence of sensory nerves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Neuropeptides activate human mast cell degranulation and chemokine production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Antimicrobial peptides human β-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Mu-opiate receptor and Beta-endorphin expression in nerve endings and keratinocytes in human skin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Inhibition of mast cell leukotriene release by thiourea derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Mast-cell infiltration of airway smooth muscle in asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Activation of betagamma subunits of G(i2) and G(i3) proteins by basic secretagogues induces exocytosis through phospholipase Cbeta and arachidonate release through phospholipase Cgamma in mast cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014572

27 November 2018

Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of histamine release induced by fluoroquinolone antibacterial agents in-vivo and in-vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutaneous responses to vasoactive intestinal polypeptide in chronic idiopathic urticaria

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypersensitivity reactions to fluoroquinolones: analysis of the factors involved

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mast cells are required for normal healing of skin wounds in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anatomical variation in mast cell nerve associations in the rat small intestine, heart, lung, and skin. Similarities of distances between neural processes and mast cells, eosinophils, or plasma cells in the jejunal lamina propria

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mast cell-MrgprB2: sensing secretagogues or a means to overreact?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical protective role of mast cells in a model of acute septic peritonitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein-coupled receptor kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mast cells in innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mast Cells Have a Pivotal Role in TNF-Independent Lymph Node Hypertrophy and the Mobilization of Langerhans Cells in Response to Bacterial Peptidoglycan

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of intestinal mast cell response in congenitally athymic mice during Trichinella spiralis infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mast cells initiate early anti-Listeria host defences

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The substance P receptor on rat mast cells and in human skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substance P induces histamine release from human pulmonary mast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased compound 48/80 induced local histamine release from nonlesional skin of patients with chronic urticaria

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histamine improves antigen uptake and cross-presentation by dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-17A modulates human airway epithelial responses to human rhinovirus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substance P-related inhibitors of mast cell exocytosis act on G-proteins or on the cell surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutaneous responses to substance P and calcitonin gene-related peptide in chronic urticaria: the effect of cetirizine and dimethindene

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of histamine release induced by levofloxacin, a fluoroquinolone antibacterial agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27448446

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JACI.2016.04.051

0 references

PMC publication ID

1 reference

PubMed publication ID

1 reference

Sitelinks

Wikipedia(0 entries)

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