(Q28079041)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

review article

3 references

27 October 2020

23 October 2022

Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

27 October 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

author name string

Pedro Laborda

series ordinal

1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Su-Yan Wang

series ordinal

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

language of work or name

1 reference

11 November 2016

4 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

27 October 2020

23 October 2022

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

27 October 2020

21

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

issue

11

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

27 March 2020

copyright license

2 references

27 October 2020

23 October 2022

0 references

Are influenza-associated morbidity and mortality estimates for those ≥ 65 in statistical databases accurate, and an appropriate test of influenza vaccine effectiveness?

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

The socio-economic burden of influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Rational design of potent sialidase-based inhibitors of influenza virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Epidemiology and pathogenesis of influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

A review of neuraminidase inhibitor susceptibility in influenza strains

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Lung consequences in adults born prematurely

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Influenza virus resistance to neuraminidase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Influenza virus assembly and budding

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Characterization of the 1918 "Spanish" influenza virus neuraminidase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Structural Characterization of the 1918 Influenza Virus H1N1 Neuraminidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Structure of the catalytic and antigenic sites in influenza virus neuraminidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Receptor recognition mechanism of human influenza A H1N1 (1918), avian influenza A H5N1 (2004), and pandemic H1N1 (2009) neuraminidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Investigation of the binding and cleavage characteristics of N1 neuraminidases from avian, seasonal, and pandemic influenza viruses using saturation transfer difference nuclear magnetic resonance.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Novel antiviral activity of neuraminidase inhibitors against an avian influenza a virus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

In the shadow of hemagglutinin: a growing interest in influenza viral neuraminidase and its role as a vaccine antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

'Flu' and structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

New millennium antivirals against pandemic and epidemic influenza: the neuraminidase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Recent progress and challenges in the discovery of new neuraminidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Influenza B virus neuraminidase can synthesize its own inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Neuraminidase inhibitors for influenza B virus infection: efficacy and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Pharmacokinetic properties of anti-influenza neuraminidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

From neuraminidase inhibitors to conjugates: a step towards better anti-influenza drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Recent advances in neuraminidase inhibitor development as anti-influenza drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Neuraminidase inhibitors for influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Influenza, a One Health paradigm--novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Emergence and pandemic potential of swine-origin H1N1 influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Advances in the structure-based design of the influenza A neuraminidase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified at the C-4 and C-9 positions and their behaviour towards sialidase from influenza virus and pig liver membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Analysis of inhibitor binding in influenza virus neuraminidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis of a new stable conformationally constrained 2,7-anhydrosialic acid derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Drugs against avian influenza a virus: design of novel sulfonate inhibitors of neuraminidase N1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis of C-4 and C-7 triazole analogs of zanamivir as multivalent sialic acid containing scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Regioselective synthesis of 4azido-Neu2en5,7Ac(2)1Me and its intramolecular transformation to 4azido-Neu2en5,9Ac(2)1Me

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally modified at the C-4 position: synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Bifunctional polymeric inhibitors of human influenza A viruses.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Coupling the Petasis condensation to an iron(III) chloride-promoted cascade provides a short synthesis of Relenza congeners

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

The Synthetic Development of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu ® ): A Challenge for Synthesis & Process Research

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Practical Total Synthesis of the Anti-Influenza Drug GS-4104

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

New, azide-free transformation of epoxides into 1,2-diamino compounds: synthesis of the anti-influenza neuraminidase inhibitor oseltamivir phosphate (Tamiflu).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Symmetry-based design for the chemoenzymatic synthesis of oseltamivir (Tamiflu) from ethyl benzoate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

New, efficient synthesis of oseltamivir phosphate (Tamiflu) via enzymatic desymmetrization of a meso-1,3-cyclohexanedicarboxylic acid diester

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Development of a concise synthesis of (-)-oseltamivir (Tamiflu)

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

A short enantioselective pathway for the synthesis of the anti-influenza neuramidase inhibitor oseltamivir from 1,3-butadiene and acrylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

A method for the synthesis of an oseltamivir PET tracer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Efficient formal synthesis of oseltamivir phosphate (Tamiflu) with inexpensive D-ribose as the starting material.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

A Synthesis of Oseltamivir (Tamiflu) Starting from d-Mannitol

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Two approaches toward the formal total synthesis of oseltamivir phosphate (Tamiflu): catalytic enantioselective three-component reaction strategy and L-glutamic acid strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Organocatalytic Michael addition of aldehydes to protected 2-amino-1-nitroethenes: the practical syntheses of oseltamivir (Tamiflu) and substituted 3-aminopyrrolidines

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

One-pot synthesis of (-)-oseltamivir and mechanistic insights into the organocatalyzed Michael reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Sugar-based synthesis of Tamiflu and its inhibitory effects on cell secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Efficient synthesis of highly active phospha-isosteres of the influenza neuraminidase inhibitor oseltamivir

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Anti-influenza virus activity of peramivir in mice with single intramuscular injection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Stereoselective total synthesis of racemic BCX-1812 (RWJ-270201) for the development of neuraminidase inhibitors as anti-influenza agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

The Henry reaction: recent examples

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Phosphonate Congeners of Oseltamivir and Zanamivir as Effective Anti-influenza Drugs: Design, Synthesis and Biological Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Synthesis of oseltamivir and tamiphosphor from N-acetyl-d-glucosamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21111513

Sialidase inhibitors related to zanamivir: synthesis and biological evaluation of 4H-pyran 6-ether and ketone

21 January 2018

1 reference

12 December 2020

Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac42en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone

1 reference

12 December 2020

Highly enantioselective direct conjugate addition of ketones to nitroalkenes promoted by a chiral primary amine-thiourea catalyst

1 reference

12 December 2020

Ring-closing metathesis-based synthesis of (3R,4R,5S)-4-acetylamino-5-amino-3-hydroxy- cyclohex-1-ene-carboxylic acid ethyl ester: a functionalized cycloalkene skeleton of GS4104

1 reference

12 December 2020

An aldol approach to the enantioselective synthesis of (-)-oseltamivir phosphate

1 reference

12 December 2020

The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase

1 reference

12 December 2020

Catalytic asymmetric anti-selective nitroaldol reaction en route to zanamivir

1 reference

12 December 2020

Synthesis of the anti-influenza agent (-)-oseltamivir free base and (-)-methyl 3-epi-shikimate

1 reference

12 December 2020

Synthesis of (-)-oseltamivir phosphate (Tamiflu) starting from cis-2,3-bis(hydroxymethyl)aziridine

1 reference

12 December 2020

Oseltamivir analog with boron cluster modulator.

1 reference

12 December 2020

Influenza treatment and prophylaxis with neuraminidase inhibitors: a review

1 reference

12 December 2020

Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range

1 reference

12 December 2020

Organocatalytic and scalable synthesis of the anti-influenza drugs zanamivir, laninamivir, and CS-8958

1 reference

12 December 2020

10.3390/MOLECULES21111513

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27845731%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

2 references