(Q28079517)

title

The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review (English)

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27672669%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1

Jon Hazeldine

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27672669%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Peter Hampson

series ordinal

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27672669%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

1 reference

21 September 2016

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27672669%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27672669%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

33

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27672669%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 4.0 International

1 June 2020

copyright license

start time

10 January 2020

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/s41038-016-0059-3

0 references

cites work

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Applications of metabolomics in cancer research

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MicroRNAs: small RNAs with a big role in gene regulation

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Genomic responses in mouse models poorly mimic human inflammatory diseases

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Use of Metabolomics to Trend Recovery and Therapy After Injury in Critically Ill Trauma Patients.

7 April 2017

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Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph

29 September 2017

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Serum Metabolic Profiling Reveals Altered Metabolic Pathways in Patients with Post-traumatic Cognitive Impairments

29 September 2017

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Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury

29 September 2017

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The effect of brain injury on the inflammatory response following severe trauma

29 September 2017

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Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma.

29 September 2017

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Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients

29 September 2017

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Mitochondrial DNA and Toll-Like Receptor-9 Are Associated With Mortality in Critically Ill Patients.

29 September 2017

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Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis.

29 September 2017

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Elevations in inflammatory cytokines are associated with poor outcomes in mechanically ventilated burn patients.

29 September 2017

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Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics

29 September 2017

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The future of murine sepsis and trauma research models

29 September 2017

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Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit

29 September 2017

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Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

29 September 2017

1 reference

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Early hemorrhage triggers metabolic responses that build up during prolonged shock.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Genomics of injury: The Glue Grant experience

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Inflammatory cytokines and their prognostic ability in cases of major burn injury

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury: A Clinical Study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

The systemic immune response to trauma: an overview of pathophysiology and treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Genomic responses in mouse models greatly mimic human inflammatory diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Use of 1H-nuclear magnetic resonance to screen a set of biomarkers for monitoring metabolic disturbances in severe burn patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Innate immune function predicts the development of nosocomial infection in critically injured children

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Prediction of multiple infections after severe burn trauma: a prospective cohort study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Cerebrospinal fluid mitochondrial DNA: a novel DAMP in pediatric traumatic brain injury

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

An integrated clinico-metabolomic model improves prediction of death in sepsis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Survivors versus nonsurvivors postburn: differences in inflammatory and hypermetabolic trajectories

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Metabolomics--a novel window into inflammatory disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Inhalation injury severity and systemic immune perturbations in burned adults

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Proteomics improves the prediction of burns mortality: results from regression spline modeling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Early interleukin-6 and slope of monocyte human leukocyte antigen-DR: a powerful association to predict the development of sepsis after major trauma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

A genomic storm in critically injured humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Concentrations of cytokines IL-6 and IL-10 in plasma of burn patients: their relationship to sepsis and outcome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Early pulmonary immune hyporesponsiveness is associated with mortality after burn and smoke inhalation injury

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Comparison of mortality associated with sepsis in the burn, trauma, and general intensive care unit patient: a systematic review of the literature

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Increases in mortality, length of stay, and cost associated with hospital-acquired infections in trauma patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Human traumatic brain injury alters plasma microRNA levels.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

IL-6 predicts organ dysfunction and mortality in patients with multiple injuries.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Early cytokine production risk stratifies trauma patients for multiple organ failure.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

A genomic score prognostic of outcome in trauma patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Multiple organ failure after trauma affects even long-term survival and functional status

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Trauma: the role of the innate immune system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Trauma patient hospital-associated infections: risks and outcomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Epidemiology of sepsis in patients with traumatic injury

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

MicroRNA let-7i is a promising serum biomarker for blast-induced traumatic brain injury.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Time course of pro- and anti-inflammatory cytokine levels in patients with burns--prognostic value of interleukin-10.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Stimulation of inflammatory markers after blunt trauma.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Risk factors for nosocomial infection in trauma patients

2 June 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficit

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

Genomic responses to inflammation in mouse models mimic humans: we concur, apples to oranges comparisons won't do.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

It's all in the genes: moving toward precision medicine in critical illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

Altered expression levels of miRNAs in serum as sensitive biomarkers for early diagnosis of traumatic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

Interleukin-10 is an independent biomarker of severe traumatic brain injury prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

Investigation of the course of proinflammatory and anti-inflammatory cytokines after burn sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

Plasma metabolite profiles following trauma-hemorrhage: effect of posttreatment with resveratrol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

Metabolic phenotyping of traumatized patients reveals a susceptibility to sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

Characterization of circulating monocytes expressing HLA-DR or CD71 and related soluble factors for 2 weeks after severe, non-thermal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS41038-016-0059-3

Early changes in frequency of peripheral blood lymphocyte subpopulations in severe traumatic brain-injured patients.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

Early versus late onset of multiple organ failure is associated with differing patterns of plasma cytokine biomarker expression and outcome after severe trauma.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030723

[Changes in human leukocyte antigen-DR expression on monocytes and its value of prediction on infection complication in trauma patients]

27 November 2018

1 reference

12 December 2020

[Changes in serum contents of interleukin-6 and interleukin-10 and their relation with occurrence of sepsis and prognosis of severely burned patients]

1 reference

12 December 2020

Neutrophil chemiluminescence in burned patients

1 reference

12 December 2020

A sequential, prospective analysis of immunologic abnormalities and infection following severe thermal injury

1 reference

12 December 2020

Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock

1 reference

12 December 2020

Metabolomics classifies phase of care and identifies risk for mortality in a porcine model of multiple injuries and hemorrhagic shock

1 reference

12 December 2020

Increased levels of interleukin-6, -8 and -10 are associated with fatal outcome following severe traumatic brain injury

1 reference

12 December 2020

10.1186/S41038-016-0059-3

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27672669%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

1013688578

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27672669%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

2 references