(Q28081113)

22 October 2020

Indole alkaloids from Catharanthus roseus: bioproduction and their effect on human health (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

1 reference

22 October 2020

Catharanthus roseus

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

author name string

Francisco Fernández-Pérez

series ordinal

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

Maria Angeles Pedreño

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

language of work or name

1 reference

12 February 2015

2 references

22 October 2020

28

1 reference

inferred from page(s)

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

22 October 2020

20

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

issue

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

page(s)

2973-3000

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

Creative Commons Attribution

13 May 2020

copyright license

1 reference

22 October 2020

0 references

Vinflunine: drug safety evaluation of this novel synthetic vinca alkaloid

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Vinflunine: a new microtubule inhibitor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Vinca drug components accumulate exclusively in leaf exudates of Madagascar periwinkle

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Purification and characterization of alpha-3',4'-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: from biochemical processing to metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

The oxidative stress response of the opportunistic fungal pathogen Candida glabrata.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Anti-cataract activity of Pterocarpus marsupium bark and Trigonella foenum-graecum seeds extract in alloxan diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus (L.) G. Don.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Yohimbine: a clinical review

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Inflammation in central nervous system injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

An update on pharmacological approaches to neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Rauwolfia serpentina in the treatment of high blood pressure; a review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effect of chromium on antioxidant potential of Catharanthus roseus varieties and production of their anticancer alkaloids: vincristine and vinblastine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Vinorelbine--a clinical review

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Oral vinorelbine in metastatic breast cancer: a review of current clinical trial results

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Structural basis for the regulation of tubulin by vinblastine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

21 January 2018

Vincristine revisited

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Instability of pleomorphic tubulin paracrystals artificially induced by Vinca alkaloids in tissue-cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Tubulin-based structure-affinity relationships for antimitotic Vinca alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Vinflunine, a novel microtubule inhibitor, suppresses calmodulin interaction with the microtubule-associated protein STOP.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Exploitation of plant cells for the production of natural compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Catharanthus terpenoid indole alkaloids: biosynthesis and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Influence of cellular differentiation and elicitation on intermediate and late steps of terpenoid indole alkaloid biosynthesis in Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

An interchangeable system of hairy root and cell suspension cultures ofCatharanthus roseus for indole alkaloid production

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Cell and tissue cultures ofCatharanthus roseus (L.) G. Don: a literature survey

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effects of stress factors, bioregulators, and synthetic precursors on indole alkaloid production in compact callus clusters cultures of Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

The role of glucose in ajmalicine production by catharanthus roseus cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Studies on production of ajmalicine in shake flasks by multiple shoot cultures of Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effect of phytohormones on growth and alkaloid accumulation by a Catharanthus roseus cell suspension cultures fed with alkaloid precursors tryptamine and loganin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effect of sodium nitroprusside on growth and terpenoid indole alkaloid production in Catharanthus roseus hairy root cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Jasmonic acid effect on the fatty acid and terpenoid indole alkaloid accumulation in cell suspension cultures of Catharanthus roseus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Differential secretion and accumulation of terpene indole alkaloids in hairy roots of Catharanthus roseus treated with methyl jasmonate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Influence of fungal elicitors on production of ajmalicine by cell cultures of Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Interaction between abscisic acid and nitric oxide in PB90-induced catharanthine biosynthesis of catharanthus roseus cell suspension cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Enhanced catharanthine and vindoline production in suspension cultures of Catharanthus roseus by ultraviolet-B light

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase over-expressing transgenic cell line T22 of Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Heteromeric and homomeric geranyl diphosphate synthases from Catharanthus roseus and their role in monoterpene indole alkaloid biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Suspension cultured transgenic cells of Nicotiana tabacum expressing tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus produce strictosidine upon secologanin feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Biotechnology for the production of plant secondary metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

The transcription factor CrWRKY1 positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

CrMPK3, a mitogen activated protein kinase from Catharanthus roseus and its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Influence of auxins on alkaloid accumulation by a transgenic cell line of Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Enhancement of ajmalicine production in Catharanthus roseus cell cultures with methyl jasmonate is dependent on timing and dosage of elicitation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

The effects of UV-B stress on the production of terpenoid indole alkaloids in Catharanthus roseus hairy roots.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Transcriptional response of the catharanthine biosynthesis pathway to methyl jasmonate/nitric oxide elicitation in Catharanthus roseus hairy root culture

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Involvement of the Octadecanoid Pathway and Protein Phosphorylation in Fungal Elicitor-Induced Expression of Terpenoid Indole Alkaloid Biosynthetic Genes inCatharanthus roseus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Modified cyclodextrins are chemically defined glucan inducers of defense responses in grapevine cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Progress in plant metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Metabolic engineering approaches for production of biochemicals in food and medicinal plants.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Strategies for the genetic modification of the medicinal plant Catharanthus roseus (L.) G. Don

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Biotransformation of tryptamine and secologanin into plant terpenoid indole alkaloids by transgenic yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20022973

Effects of NaCl on the growth and alkaloid content of Catharanthus roseus seedlings

21 January 2018

1 reference

12 December 2020

Validated HILIC-MS/MS assay for determination of vindesine in human plasma: Application to a population pharmacokinetic study

1 reference

12 December 2020

Vacuolar transport of the medicinal alkaloids from Catharanthus roseus is mediated by a proton-driven antiport

1 reference

12 December 2020

Enhanced catharanthine production in catharanthus roseus cell cultures by combined elicitor treatment in shake flasks and bioreactors

1 reference

12 December 2020

[Thermodynamics of calmodulin and tubulin binding to the vinca-alkaloid vinorelbine].

1 reference

12 December 2020

Overexpression of an apoplastic peroxidase gene CrPrx in transgenic hairy root lines of Catharanthus roseus

1 reference

12 December 2020

New method to enhance ajmalicine production in Catharanthus roseus cell cultures based on the use of cyclodextrins

1 reference

12 December 2020

Selective and reversible effects of vinca alkaloids on Trypanosoma cruzi epimastigote forms: blockage of cytokinesis without inhibition of the organelle duplication

1 reference

12 December 2020

The Catharanthus alkaloids: pharmacognosy and biotechnology

1 reference

12 December 2020

Razoxane and vindesine in advanced soft tissue sarcomas: impact on metastasis, survival and radiation response.

1 reference

12 December 2020

The effect of inoculum density and conditioned medium on the production of ajmalicine and catharanthine from immobilized Catharanthus roseus cells

1 reference

12 December 2020

The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots

1 reference

12 December 2020

Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats

1 reference

12 December 2020

Inflammatory processes in Alzheimer's disease

1 reference

12 December 2020

1 reference

12 December 2020

Alkaloid Production in Root and Shoot Cultures of Catharanthus roseus

1 reference

12 December 2020

Effects of long-term preservation on growth and productivity of Panax ginseng and Catharanthus roseus cell cultures

1 reference

12 December 2020

Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures

1 reference

12 December 2020

Production of indole alkaloids by selected hairy root lines ofCatharanthus roseus

1 reference

12 December 2020

The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics

1 reference

12 December 2020

Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice

1 reference

12 December 2020

Long-term survival results of a randomized phase III trial of vinflunine plus best supportive care versus best supportive care alone in advanced urothelial carcinoma patients after failure of platinum-based chemotherapy

1 reference

12 December 2020

10.3390/MOLECULES20022973

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

3064016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

3064016

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json

13 May 2020

PubMed publication ID

25685907

2 references

Consolidated OpenCitations Corpus – April 2017

3064016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272713&resulttype=core&format=json