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Integrator: surprisingly diverse functions in gene expression
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title
Integrator: surprisingly diverse functions in gene expression
(English)
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author name string
David Baillat
series ordinal
1
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Eric J. Wagner
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2
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language of work or name
English
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publication date
May 2015
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published in
Trends in Biochemical Sciences
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volume
40
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PubMed
issue
5
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PubMed
page(s)
257-64
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PubMed
cites work
RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation
1 reference
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PubMed Central
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Rtr1 Is a Dual Specificity Phosphatase That Dephosphorylates Tyr1 and Ser5 on the RNA Polymerase II CTD
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PubMed Central
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The RNA polymerase II carboxy-terminal domain (CTD) code
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PubMed Central
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Serine phosphorylation and proline isomerization in RNAP II CTD control recruitment of Nrd1
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20 March 2017
The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity
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PubMed Central
reference URL
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20 March 2017
Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes
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PubMed Central
reference URL
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20 March 2017
GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein
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PubMed Central
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20 March 2017
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
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PubMed Central
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20 March 2017
SOSS complexes participate in the maintenance of genomic stability
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PubMed Central
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20 March 2017
HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response
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PubMed Central
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20 March 2017
TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.
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PubMed Central
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20 March 2017
Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation
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PubMed Central
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Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme
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Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II
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PubMed Central
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20 March 2017
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.
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PubMed Central
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20 March 2017
Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family
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20 March 2017
Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes
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The Mediator complex and transcription regulation
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Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail
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PubMed Central
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The multitalented Mediator complex
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PubMed Central
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20 March 2017
Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres
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20 March 2017
Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation
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PubMed Central
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Transcription termination by nuclear RNA polymerases
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PubMed Central
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The Integrator complex controls the termination of transcription at diverse classes of gene targets
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29 September 2017
Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes.
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PubMed Central
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29 September 2017
Integrator regulates transcriptional initiation and pause release following activation
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PubMed Central
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29 September 2017
Vertebrate Ssu72 regulates and coordinates 3'-end formation of RNAs transcribed by RNA polymerase II.
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29 September 2017
RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells.
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29 September 2017
Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processing
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29 September 2017
Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery
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29 September 2017
The Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycle
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29 September 2017
A day in the life of the spliceosome
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PubMed Central
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29 September 2017
A core hSSB1-INTS complex participates in the DNA damage response
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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29 September 2017
GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination
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PubMed Central
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29 September 2017
Non-mRNA 3' end formation: how the other half lives
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PubMed Central
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29 September 2017
The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.
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29 September 2017
An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.
1 reference
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PubMed Central
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29 September 2017
R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters
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PubMed Central
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29 September 2017
snRNA 3' end formation requires heterodimeric association of integrator subunits
1 reference
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PubMed Central
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29 September 2017
Prolonged α-amanitin treatment of cells for studying mutated polymerases causes degradation of DSIF160 and other proteins
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PubMed Central
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29 September 2017
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing
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PubMed Central
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29 September 2017
Human GTPases associate with RNA polymerase II to mediate its nuclear import
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PubMed Central
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29 September 2017
Analysis of the human endogenous coregulator complexome.
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PubMed Central
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29 September 2017
A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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29 September 2017
Regulation of snRNA gene expression by the Drosophila melanogaster small nuclear RNA activating protein complex (DmSNAPc).
1 reference
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PubMed Central
reference URL
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29 September 2017
snRNA 3' end formation: the dawn of the Integrator complex
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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29 September 2017
Streamlined analysis schema for high-throughput identification of endogenous protein complexes
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PubMed Central
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29 September 2017
INTS3 controls the hSSB1-mediated DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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29 September 2017
Transcriptional regulation of human small nuclear RNA genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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29 September 2017
The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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29 September 2017
Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
retrieved
29 September 2017
Formation of the 3' end of U1 snRNA is directed by a conserved sequence located downstream of the coding region
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
retrieved
29 September 2017
Human snRNA genes use polyadenylation factors to promote efficient transcription termination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
retrieved
2 June 2018
Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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2 June 2018
Deciphering the RNA polymerase II CTD code in fission yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
retrieved
2 June 2018
The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
retrieved
2 June 2018
Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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2 June 2018
P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
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2 June 2018
DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
retrieved
27 November 2018
CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408249
retrieved
27 November 2018
Metaphase fragility of the human RNU1 and RNU2 loci is induced by actinomycin D through a p53-dependent pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25882383
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TIBS.2015.03.005
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1715239
OpenCitations bibliographic resource ID
1715239
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1715239
PMC publication ID
4408249
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1715239
PubMed publication ID
25882383
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1715239
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