(Q28083686)

title

DNA damage control: regulation and functions of checkpoint kinase 1 (English)

1 reference

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216057%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

David A Gillespie

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216057%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

author name string

Veronique A. J. Smits

series ordinal

1

1 reference

David A. Gillespie

series ordinal

2

1 reference

language of work or name

1 reference

October 2015

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216057%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

volume

282

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216057%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

issue

19

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216057%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

page(s)

3681-3692

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216057%20AND%20SRC:MED&resulttype=core&format=json

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

15 June 2020

cites work

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The decision to enter mitosis: feedback and redundancy in the mitotic entry network

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Rapid destruction of human Cdc25A in response to DNA damage

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Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

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Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

21 January 2018

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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

21 January 2018

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DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function

21 January 2018

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Nuclear Chk1 prevents premature mitotic entry.

21 January 2018

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Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

21 January 2018

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Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication.

21 January 2018

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Clusters, factories and domains: The complex structure of S-phase comes into focus.

21 January 2018

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Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories.

21 January 2018

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Tight Chk1 Levels Control Replication Cluster Activation in Xenopus

21 January 2018

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The ATR pathway: fine-tuning the fork

21 January 2018

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

21 January 2018

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Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation

21 January 2018

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Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures.

21 January 2018

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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

21 January 2018

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The structural determinants of checkpoint activation

21 January 2018

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

21 January 2018

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage

21 January 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

1 reference

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Specific role of Chk1 phosphorylations in cell survival and checkpoint activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

21 January 2018

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Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

21 January 2018

1 reference

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Regulatory motifs in Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Regulation of Chk1 by its C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Coupling cellular localization and function of checkpoint kinase 1 (Chk1) in checkpoints and cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3.

21 January 2018

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

1 reference

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A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function

21 January 2018

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The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle

21 January 2018

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Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

21 January 2018

1 reference

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SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

21 January 2018

1 reference

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Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

CRL4(CDT2) targets CHK1 for PCNA-independent destruction

21 January 2018

1 reference

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Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

21 January 2018

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USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

USP7 controls Chk1 protein stability by direct deubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Lack of PTEN sequesters CHK1 and initiates genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Akt1 inhibits homologous recombination in Brca1-deficient cells by blocking the Chk1-Rad51 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Chk1 is required for spindle checkpoint function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Phosphorylation at serine 331 is required for Aurora B activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Polo-like kinase-1 is a target of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387

Kinases charging to the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13387