(Q33963490)

30 July 2017

Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage (English)

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30 July 2017

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N Xu

1

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30 July 2017

S Libertini

2

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E J Black

3

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30 July 2017

Y Lao

4

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30 July 2017

N Hegarat

5

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M Walker

6

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D A Gillespie

7

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30 July 2017

language of work or name

English

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publication date

18 July 2011

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30 July 2017

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30 July 2017

31

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9

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30 July 2017

1086-1094

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https://scigraph.springernature.com/pub.10.1038/onc.2011.310

30 July 2017

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cites work

DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Overall Cdk activity modulates the DNA damage response in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

DNA double-strand break repair: from mechanistic understanding to cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

CDK targets Sae2 to control DNA-end resection and homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.310

Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Specific role of Chk1 phosphorylations in cell survival and checkpoint activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

The G2-phase DNA-damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Mechanism of eukaryotic homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Mechanism of homologous recombination: mediators and helicases take on regulatory functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Dual role of CDKs in DNA repair: to be, or not to be.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.310

21 January 2018

Identifiers

DOI

10.1038/ONC.2011.310

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Dimensions Publication ID

30 July 2017

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