(Q39786213)

14 September 2017

title

DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2. (English)

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14 September 2017

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E Bourke

1

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Helfrid Hochegger

object named as

H Hochegger

4

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Shunichi Takeda

object named as

S Takeda

3

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author name string

J A L Brown

2

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14 September 2017

C G Morrison

5

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14 September 2017

language of work or name

English

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publication date

19 October 2009

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14 September 2017

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14 September 2017

volume

29

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14 September 2017

issue

4

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14 September 2017

page(s)

616-624

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Cdc2-cyclin E complexes regulate the G1/S phase transition

14 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Overexpression of cyclin A in human HeLa cells induces detachment of kinetochores and spindle pole/centrosome overproduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Cdk2 knockout mice are viable

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Cell-specific responses to loss of cyclin-dependent kinases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Centrosome biogenesis and function: centrosomics brings new understanding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

DNA damage induces Chk1-dependent centrosome amplification.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Involvement of centrosome amplification in radiation-induced mitotic catastrophe

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Centrosomes in cellular regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Oncogenes and tumour suppressors take on centrosomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Abnormal centrosome amplification in the absence of p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

A mechanism linking extra centrosomes to chromosomal instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Cyclin-dependent kinase control of centrosome duplication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Rapid destruction of human Cdc25A in response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

The cyclin A1-CDK2 complex regulates DNA double-strand break repair.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Origins and consequences of centrosome aberrations in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Molecular dissection of the centrosome overduplication pathway in S-phase-arrested cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Centriole separation in DNA damage-induced centrosome amplification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Deregulated cyclin E induces chromosome instability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Loss of p53 and centrosome hyperamplification.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Mechanism limiting centrosome duplication to once per cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Centrosome number is controlled by a centrosome-intrinsic block to reduplication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.340

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.340

1 reference

Dimensions Publication ID

14 September 2017

1014005128

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1 reference