(Q37001380)

17 August 2017

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title

Oncogenes and tumour suppressors take on centrosomes (English)

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17 August 2017

Kenji Fukasawa

1

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17 August 2017

language of work or name

English

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publication date

1 December 2007

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17 August 2017

published in

Nature Reviews Cancer

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17 August 2017

volume

7

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17 August 2017

issue

12

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17 August 2017

page(s)

911-924

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Two for two: Cdk2 and its role in centrosome doubling

17 August 2017

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Rules to replicate by

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

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31 March 2020

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Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

31 March 2020

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Translocation of nucleolar phosphoprotein B23 (37 kDa/pI 5.1) induced by selective inhibitors of ribosome synthesis

31 March 2020

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Nucleolar protein B23 has molecular chaperone activities

31 March 2020

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Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease

31 March 2020

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The carboxyl terminal sequence of nucleolar protein B23.1 is important in its DNA polymerase alpha-stimulatory activity

31 March 2020

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Major nucleolar proteins shuttle between nucleus and cytoplasm

31 March 2020

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Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing

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Nucleophosmin is selectively deposited on mRNA during polyadenylation

31 March 2020

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31 March 2020

Nucleophosmin and cancer

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Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity

31 March 2020

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Role of nucleophosmin in embryonic development and tumorigenesis

31 March 2020

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Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity

31 March 2020

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Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

31 March 2020

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Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes

31 March 2020

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Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication

31 March 2020

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The Rho-associated protein kinase p160ROCK is required for centrosome positioning

31 March 2020

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The Rho kinases I and II regulate different aspects of myosin II activity

31 March 2020

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The mouse Mps1p-like kinase regulates centrosome duplication

31 March 2020

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Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

31 March 2020

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

31 March 2020

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Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

31 March 2020

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RNA polymerase II transcription is required for human papillomavirus type 16 E7- and hydroxyurea-induced centriole overduplication

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31 March 2020

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Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy.

31 March 2020

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RB and cell cycle progression

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31 March 2020

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31 March 2020

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31 March 2020

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Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

31 March 2020

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Activation and activities of the p53 tumour suppressor protein

31 March 2020

1 reference

Abnormal centrosome amplification in the absence of p53.

31 March 2020

1 reference

Genomic instability and apoptosis are frequent in p53 deficient young mice

31 March 2020

1 reference

Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

31 March 2020

1 reference

Divorcing ARF and p53: an unsettled case

31 March 2020

1 reference

Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes.

31 March 2020

1 reference

p53 localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines, and a human primary culture: An immunofluorescence study

31 March 2020

1 reference

Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53.

31 March 2020

1 reference

p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.

31 March 2020

1 reference

Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication

31 March 2020

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Mdm2: A regulator of cell growth and death

31 March 2020

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Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression.

31 March 2020

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Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

31 March 2020

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Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer

31 March 2020

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Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis

31 March 2020

1 reference

Polo-like kinase-2 is required for centriole duplication in mammalian cells

31 March 2020

1 reference

The Polo kinase Plk4 functions in centriole duplication

31 March 2020

1 reference

A Novel Mammalian, Mitotic Spindle–associated Kinase Is Related to Yeast and Fly Chromosome Segregation Regulators

31 March 2020

1 reference

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

31 March 2020

1 reference

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

31 March 2020

1 reference

The RAD51 gene family, genetic instability and cancer

31 March 2020

1 reference

Cancer susceptibility and the functions of BRCA1 and BRCA2

31 March 2020

1 reference

BRCA1 is associated with the centrosome during mitosis.

31 March 2020

1 reference

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

31 March 2020

1 reference

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number

31 March 2020

1 reference

Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization

31 March 2020

1 reference

Subcellular localization of the BRCA1 gene product in mitotic cells

31 March 2020

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Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes.

31 March 2020

1 reference

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b

31 March 2020

1 reference

Rad51 recombinase and recombination mediators

31 March 2020

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Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.

31 March 2020

1 reference

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

31 March 2020

1 reference

Extensive chromosomal instability in Rad51d-deficient mouse cells

31 March 2020

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Haploinsufficiency of RAD51B causes centrosome fragmentation and aneuploidy in human cells

31 March 2020

1 reference

RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis

31 March 2020

1 reference

Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

31 March 2020

1 reference

Suppression of centrosome amplification after DNA damage depends on p27 accumulation

31 March 2020

1 reference

Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells

31 March 2020

1 reference

Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint

31 March 2020

1 reference

Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure

31 March 2020

1 reference

Regulation of the G2/M transition by p53.

31 March 2020

1 reference

Universal control mechanism regulating onset of M-phase

31 March 2020

1 reference

p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress

31 March 2020

1 reference

Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

31 March 2020

1 reference

The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase

31 March 2020

1 reference

Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

31 March 2020

1 reference

Active cyclin B1-Cdk1 first appears on centrosomes in prophase

31 March 2020

1 reference

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

31 March 2020

1 reference

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

31 March 2020

1 reference

Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function

31 March 2020

1 reference

PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression

31 March 2020

1 reference

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

31 March 2020

1 reference

The Ran GTPase: theme and variations

31 March 2020

1 reference

Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles

31 March 2020

1 reference

The mechanism of spindle assembly: functions of Ran and its target TPX2

31 March 2020

1 reference

Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells

31 March 2020

1 reference

Mammalian RanBP1 regulates centrosome cohesion during mitosis

31 March 2020

1 reference

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

31 March 2020

1 reference

Human TPX2 is required for targeting Aurora-A kinase to the spindle

31 March 2020

1 reference

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

31 March 2020

1 reference

A novel mechanism for activation of the protein kinase Aurora A

31 March 2020

1 reference

BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition

31 March 2020

1 reference

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion

31 March 2020

1 reference

Rootletin forms centriole-associated filaments and functions in centrosome cohesion

31 March 2020

1 reference

Nek2 kinase in chromosome instability and cancer

31 March 2020

1 reference

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

31 March 2020

1 reference

Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles

31 March 2020

1 reference

31 March 2020

1 reference

Protein phosphatase-1alpha regulates centrosome splitting through Nek2.

31 March 2020

1 reference

Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases

31 March 2020

1 reference

The bimC family of kinesins: essential bipolar mitotic motors driving centrosome separation

31 March 2020

1 reference

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

31 March 2020

1 reference

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

31 March 2020

1 reference

The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5

31 March 2020

1 reference

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle

31 March 2020

1 reference

Centrosomes and cancer: lessons from a TACC.

31 March 2020

1 reference

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.

31 March 2020

1 reference

XMAP215: a key component of the dynamic microtubule cytoskeleton

31 March 2020

1 reference

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

31 March 2020

1 reference

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

31 March 2020

1 reference

Lats2 is an essential mitotic regulator required for the coordination of cell division

31 March 2020

1 reference

LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis

31 March 2020

1 reference

p21-activated kinases in cancer

31 March 2020

1 reference

The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

31 March 2020

1 reference

Polo-like kinases and the orchestration of cell division

31 March 2020

1 reference

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation

31 March 2020

1 reference

Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases

31 March 2020

1 reference

Katanin-mediated microtubule severing can be regulated by multiple mechanisms

31 March 2020

1 reference

Regulation of Op18 during spindle assembly in Xenopus egg extracts.

31 March 2020

1 reference

Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

31 March 2020

1 reference

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.

31 March 2020

1 reference

The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

31 March 2020

1 reference

Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

31 March 2020

1 reference

The spindle checkpoint: structural insights into dynamic signalling

31 March 2020

1 reference

Regulation of APC-Cdc20 by the spindle checkpoint

31 March 2020

1 reference

Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1

31 March 2020

1 reference

Centrosome composition and microtubule anchoring mechanisms

31 March 2020

1 reference

Gamma-tubulin complexes and microtubule nucleation

31 March 2020

1 reference

Gamma-tubulin complexes and their interaction with microtubule-organizing centers

31 March 2020

1 reference

Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function

31 March 2020

1 reference

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

31 March 2020

1 reference

Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

The role of cyclin E in cell proliferation, development and cancer

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC2249

1 reference

17 August 2017

1 reference