(Q36849329)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17568790%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

review article

1 reference

title

CDC25 phosphatases in cancer cells: key players? Good targets? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17568790%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

2

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31 December 2019

Bernard Ducommun

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17568790%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

author name string

Rose Boutros

series ordinal

1

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31 December 2019

language of work or name

English

0 references

publication date

1 July 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17568790%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

published in

Nature Reviews Cancer

1 reference

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31 December 2019

volume

7

1 reference

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31 December 2019

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17568790%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

page(s)

495-507

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17568790%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc2169

31 December 2019

exact match

0 references

cites work

What if higher plants lack a CDC25 phosphatase?

1 reference

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

21 January 2018

1 reference

Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2

21 January 2018

1 reference

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase

21 January 2018

1 reference

Isolation of a cDNA encoding the X enopus homologue of mammalian Cdc25A that can induce meiotic maturation of oocytes

21 January 2018

1 reference

Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C

21 January 2018

1 reference

Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?

21 January 2018

1 reference

Multiple splicing variants of cdc25B regulate G2/M progression

21 January 2018

1 reference

cdc25+ functions as an inducer in the mitotic control of fission yeast.

21 January 2018

1 reference

Mammalian cyclin-dependent kinases

21 January 2018

1 reference

The cdk-activating kinase (CAK): from yeast to mammals.

21 January 2018

1 reference

Cdc25 phosphatases and cancer

21 January 2018

1 reference

Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases

21 January 2018

1 reference

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

21 January 2018

1 reference

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

21 January 2018

1 reference

Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome.

21 January 2018

1 reference

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

21 January 2018

1 reference

The when and wheres of CDC25 phosphatases

21 January 2018

1 reference

p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

21 January 2018

1 reference

Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells.

21 January 2018

1 reference

Antisense phosphorothioate oligonucleotides specifically down-regulate cdc25B causing S-phase delay and persistent antiproliferative effects.

21 January 2018

1 reference

Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases

21 January 2018

1 reference

Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

21 January 2018

1 reference

CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.

21 January 2018

1 reference

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

21 January 2018

1 reference

Protein kinase CK2 regulates CDC25B phosphatase activity

21 January 2018

1 reference

Polo-like kinases and the orchestration of cell division

21 January 2018

1 reference

Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts

21 January 2018

1 reference

Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis

21 January 2018

1 reference

21 January 2018

The Plk3-Cdc25 circuit

1 reference

Plk1 promotes nuclear translocation of human Cdc25C during prophase

21 January 2018

1 reference

14-3-3 proteins in cell cycle regulation

21 January 2018

1 reference

Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase

21 January 2018

1 reference

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

21 January 2018

1 reference

CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage.

21 January 2018

1 reference

CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis

21 January 2018

1 reference

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

21 January 2018

1 reference

Dual mode of degradation of Cdc25 A phosphatase

21 January 2018

1 reference

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

21 January 2018

1 reference

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

21 January 2018

1 reference

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

21 January 2018

1 reference

Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation

21 January 2018

1 reference

Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases

21 January 2018

1 reference

ATM and ATR: components of an integrated circuit

21 January 2018

1 reference

Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint

21 January 2018

1 reference

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

21 January 2018

1 reference

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

21 January 2018

1 reference

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

1 reference

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

21 January 2018

1 reference

The p38-mediated stress-activated checkpoint. A rapid response system for delaying progression through antephase and entry into mitosis

21 January 2018

1 reference

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

21 January 2018

1 reference

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

21 January 2018

1 reference

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

21 January 2018

1 reference

Induction of Cdc25B regulates cell cycle resumption after genotoxic stress

21 January 2018

1 reference

Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri- and post-menopausal breast cancer.

21 January 2018

1 reference

CDC25 phosphatases as potential human oncogenes

21 January 2018

1 reference

Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer

21 January 2018

1 reference

Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer.

21 January 2018

1 reference

Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus

21 January 2018

1 reference

Prediction of the response to chemoradiation and prognosis in oesophageal squamous cancer

21 January 2018

1 reference

Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine

21 January 2018

1 reference

Expression of cdc25A and cdc25B proteins in thyroid neoplasms

21 January 2018

1 reference

Expression of cdc25B and cdc25A in medullary thyroid carcinoma: cdc25B expression level predicts a poor prognosis

21 January 2018

1 reference

Expression patterns of cyclin E, cyclin A and CDC25 phosphatases in laryngeal carcinogenesis.

21 January 2018

1 reference

Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas.

21 January 2018

1 reference

Expression and functional significance of CDC25B in human pancreatic ductal adenocarcinoma

21 January 2018

1 reference

Prognostic significance of CDC25B expression in gliomas

21 January 2018

1 reference

c-Myc oncogene and Cdc25A cell activating phosphatase expression in non-Hodgkin's lymphoma.

21 January 2018

1 reference

Cdc25 cell-cycle phosphatase as a target of c-myc

21 January 2018

1 reference

Involvement of Myc targets in c-myc and N-myc induced human tumors

21 January 2018

1 reference

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

21 January 2018

1 reference

E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression

21 January 2018

1 reference

Regulation of mitotic entry by microcephalin and its overlap with ATR signalling

21 January 2018

1 reference

Regulation of lung cancer cell growth and invasiveness by beta-TRCP.

21 January 2018

1 reference

Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

1 reference

Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors

21 January 2018

1 reference

Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability.

21 January 2018

1 reference

Induction of mammary gland hyperplasia in transgenic mice over-expressing human Cdc25B.

21 January 2018

1 reference

Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis

21 January 2018

1 reference

A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2

21 January 2018

1 reference

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

Targeting cell cycle and apoptosis for the treatment of human malignancies

21 January 2018

1 reference

Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia

21 January 2018

1 reference

A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days

21 January 2018

1 reference

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

21 January 2018

1 reference

Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase

21 January 2018

1 reference

Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp.

21 January 2018

1 reference

Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.

21 January 2018

1 reference

H32, a non-quinone sulfone analog of vitamin K3, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating ERK.

21 January 2018

1 reference

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes

21 January 2018

1 reference

Catalytic and chemical competence of regulation of cdc25 phosphatase by oxidation/reduction

21 January 2018

1 reference

Fluorinated Cpd 5, a pure arylating K-vitamin derivative, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating MAPK.

21 January 2018

1 reference

A novel synthetic inhibitor of CDC25 phosphatases: BN82002.

21 January 2018

1 reference

Inhibiting transient protein-protein interactions: lessons from the Cdc25 protein tyrosine phosphatases

21 January 2018

1 reference

Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent

21 January 2018

1 reference

New approaches to molecular cancer therapeutics

21 January 2018

1 reference

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics

21 January 2018

1 reference

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

21 January 2018

1 reference

Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

21 January 2018

1 reference

Cancer: stem cells and brain tumours.

21 January 2018

1 reference

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

1 reference

Restarting the cell cycle when the checkpoint comes to a halt

21 January 2018

1 reference

APC/CTNNB1 (?-catenin) pathway alterations in human prostate cancers

21 January 2018

1 reference

Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B

21 January 2018

1 reference

Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition

31 March 2020

1 reference

Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events

31 March 2020

1 reference

Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/Cdc2 but not cyclin A/Cdk2

31 March 2020

1 reference

Cdc25: mechanisms of checkpoint inhibition and recovery

31 March 2020

1 reference

The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase

31 March 2020

1 reference

Regulation of CDC25B phosphatases subcellular localization

31 March 2020

1 reference

Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events

31 March 2020

1 reference

DNA damage checkpoints in mammals

31 March 2020

1 reference

CDC25B phosphorylation by p38 and MK-2

31 March 2020

1 reference

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

31 March 2020

1 reference

Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expression

31 March 2020

1 reference

Role of the Cdc25A phosphatase in human breast cancer

31 March 2020

1 reference

Expression of cdc25A and cdc25B phosphatase in breast carcinoma

31 March 2020

1 reference

Expression of the cdc25B gene as a prognosis marker in non-small cell lung cancer

31 March 2020

1 reference

Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma

31 March 2020

1 reference

p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy

31 March 2020

1 reference

Alteration of G2 cell cycle regulators occurs during carcinogenesis of the endometrium

31 March 2020

1 reference

Expression of the cdc25B mRNA correlated with that of N-myc in neuroblastoma

31 March 2020

1 reference

cdc25a and the splicing variant cdc25b2, but not cdc25B1, -B3 or -C, are over-expressed in aggressive human non-Hodgkin's lymphomas

31 March 2020

1 reference

Reciprocal Cdc25A and p27 expression in B-cell non-Hodgkin lymphomas

31 March 2020

1 reference

Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines

31 March 2020

1 reference

Somatic mutations of the beta-TrCP gene in gastric cancer

31 March 2020

1 reference

Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms

31 March 2020

1 reference

Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice

31 March 2020

1 reference

Inhibitors of cyclin-dependent kinase modulators for cancer therapy.

31 March 2020

1 reference

Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25

31 March 2020

1 reference

Naphthoquinone analogs as inactivators of cdc25 phosphatase

31 March 2020

1 reference

A fission yeast strain expressing human CDC25A phosphatase: a tool for selectivity studies of pharmacological inhibitors of CDC25.

31 March 2020

1 reference

PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo

31 March 2020

1 reference

Pharmacologic inhibition of CDC25 phosphatases impairs interphase microtubule dynamics and mitotic spindle assembly

31 March 2020

1 reference

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

1 reference

Differential mitotic degradation of the CDC25B phosphatase variants.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC2169

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17568790%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference