(Q28182301)

4

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Avram Hershko

7

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Michele Pagano

Nicolino Valerio Dorrello

8

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6

N Valerio Dorrello

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Luca Busino

1

Luca Busino

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Maddalena Donzelli

2

Maddalena Donzelli

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Giulio F Draetta

9

Giulio F Draetta

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author name string

Massimo Chiesa

3

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Dvora Ganoth

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

5

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language of work or name

English

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publication date

6 November 2003

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published in

Nature

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volume

426

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issue

6962

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page(s)

87-91

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cites work

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7 January 2021

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

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7 January 2021

Rapid destruction of human Cdc25A in response to DNA damage

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Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

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Mammalian G1- and S-phase checkpoints in response to DNA damage

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

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7 January 2021

Dual mode of degradation of Cdc25 A phosphatase

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The SCF ubiquitin ligase: an extended look

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Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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7 January 2021

Identification of a family of human F-box proteins

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The F-box protein family.

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

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7 January 2021

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase

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7 January 2021

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

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Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

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Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

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7 January 2021

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

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7 January 2021

Radiosensitivity in ataxia-telangiectasia: a new explanation

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7 January 2021

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

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7 January 2021

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

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Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

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7 January 2021

Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele

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7 January 2021

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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