(Q45345467)

13 December 2017

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. (English)

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13 December 2017

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8

Ralph B Arlinghaus

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13 December 2017

Hiroshi Katayama

1

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13 December 2017

Kaori Sasai

2

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13 December 2017

Hidehiko Kawai

3

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13 December 2017

Zhi-Min Yuan

4

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13 December 2017

Jolanta Bondaruk

5

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13 December 2017

Fumio Suzuki

6

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13 December 2017

Satoshi Fujii

7

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13 December 2017

Bogdan A Czerniak

9

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13 December 2017

Subrata Sen

10

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13 December 2017

language of work or name

English

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publication date

14 December 2003

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13 December 2017

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13 December 2017

36

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13 December 2017

1

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13 December 2017

55-62

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https://scigraph.springernature.com/pub.10.1038/ng1279

13 December 2017

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cites work

Mitotic kinases as regulators of cell division and its checkpoints

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7 January 2021

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

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7 January 2021

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

1 reference

7 January 2021

The centrosome-associated Aurora/Ipl-like kinase family

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7 January 2021

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

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7 January 2021

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

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7 January 2021

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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7 January 2021

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

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7 January 2021

Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

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7 January 2021

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

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7 January 2021

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle

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7 January 2021

Abnormal centrosome amplification in the absence of p53.

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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7 January 2021

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

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7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

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7 January 2021

SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

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7 January 2021

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

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7 January 2021

Inhibition of Bcr serine kinase by tyrosine phosphorylation

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7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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7 January 2021

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

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7 January 2021

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

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7 January 2021

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

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7 January 2021

Surfing the p53 network

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7 January 2021

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

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7 January 2021

The MDM2 RING-finger domain is required to promote p53 nuclear export

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7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

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7 January 2021

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

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7 January 2021

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

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7 January 2021

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

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7 January 2021

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

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7 January 2021

Regulation of p53 function

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7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

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7 January 2021

Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase

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7 January 2021

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases

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7 January 2021

Dynamic association of a tumor amplified kinase, Aurora‐A, with the centrosome and mitotic spindle

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7 January 2021

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

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7 January 2021

Human TPX2 is required for targeting Aurora-A kinase to the spindle

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7 January 2021

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

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7 January 2021

Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent

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7 January 2021

Identifiers

DOI

10.1038/NG1279

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Dimensions Publication ID

13 December 2017

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