(Q28242189)

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

31 March 2020

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Biology of the p21-activated kinases

31 March 2020

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

31 March 2020

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Regulation of cell function by Rho family GTPases

31 March 2020

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Ras and Rho GTPases: a family reunion

31 March 2020

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p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

31 March 2020

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Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

31 March 2020

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Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

31 March 2020

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The Akt proto-oncogene links Ras to Pak and cell survival signals

31 March 2020

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Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

31 March 2020

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High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer

31 March 2020

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Negative control of the Myc protein by the stress-responsive kinase Pak2

31 March 2020

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A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway.

31 March 2020

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Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts

31 March 2020

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Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

31 March 2020

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Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes

31 March 2020

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p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells

31 March 2020

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Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase

31 March 2020

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Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

31 March 2020

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Overexpression of βPix-a in human breast cancer tissues

31 March 2020

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A role for Pak protein kinases in Schwann cell transformation

31 March 2020

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p21-activated kinase links Rac/Cdc42 signaling to merlin

31 March 2020

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Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

31 March 2020

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Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

31 March 2020

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Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

31 March 2020

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Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

31 March 2020

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Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

31 March 2020

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Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer

31 March 2020

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P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium

31 March 2020

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PAK1 hyperactivation is sufficient for mammary gland tumor formation

31 March 2020

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P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation

31 March 2020

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Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

31 March 2020

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AR and ER interaction with a p21-activated kinase (PAK6)

31 March 2020

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

31 March 2020

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Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

31 March 2020

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Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

31 March 2020

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Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3.

31 March 2020

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Identification of the regulatory autophosphorylation site of autophosphorylation-dependent protein kinase (auto-kinase). Evidence that auto-kinase belongs to a member of the p21-activated kinase family

31 March 2020

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Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

31 March 2020

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A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

31 March 2020

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Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

31 March 2020

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The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

31 March 2020

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Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology

31 March 2020

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Cell cycle-regulated phosphorylation of p21-activated kinase 1.

31 March 2020

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Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis

31 March 2020

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Regulation of Xenopus p21-activated kinase (X-PAK2) by Cdc42 and maturation-promoting factor controls Xenopus oocyte maturation

31 March 2020

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Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

31 March 2020

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Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase

31 March 2020

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The Ste20 group kinases as regulators of MAP kinase cascades

31 March 2020

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PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

31 March 2020

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Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

31 March 2020

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

31 March 2020

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

31 March 2020

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Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK

31 March 2020

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LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system

31 March 2020

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LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer

31 March 2020

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A role for LIM kinase in cancer invasion.

31 March 2020

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p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate

31 March 2020

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Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

31 March 2020

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Microtubule polymerization dynamics

31 March 2020

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Microtubules as a target for anticancer drugs

31 March 2020

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The oncoprotein 18/stathmin family of microtubule destabilizers

31 March 2020

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Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16

31 March 2020

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Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.

31 March 2020

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p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B

31 March 2020

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Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

31 March 2020

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Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)

31 March 2020

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p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils

31 March 2020

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

31 March 2020

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A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase

31 March 2020

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Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase

31 March 2020

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p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

31 March 2020

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p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts

31 March 2020

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The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

31 March 2020

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p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

31 March 2020

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Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes

31 March 2020

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

31 March 2020

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

31 March 2020

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Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells

31 March 2020

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Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

31 March 2020

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p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Ikappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection

31 March 2020

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Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

31 March 2020

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Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

31 March 2020

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Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

31 March 2020

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PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: Evidence for the involvement of oxidative stress

31 March 2020

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Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

31 March 2020

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Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression

31 March 2020

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Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions

31 March 2020

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Functional inactivation of a transcriptional corepressor by a signaling kinase

31 March 2020

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Evidence for a function of CtBP in epithelial gene regulation and anoikis

31 March 2020

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The p21-activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe

31 March 2020

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Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands

31 March 2020

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Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer

31 March 2020

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A dominant-negative p65 PAK peptide inhibits angiogenesis.

31 March 2020

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The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation

31 March 2020

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Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)

31 March 2020

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Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway.

31 March 2020

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Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance

31 March 2020

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

31 March 2020

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Structure of Cdc42 bound to the GTPase binding domain of PAK

31 March 2020

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p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

31 March 2020

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Nuclear localization and chromatin targets of p21-activated kinase 1

31 March 2020

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Signaling to chromatin through histone modifications

31 March 2020

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Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation

31 March 2020

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Function and regulation of Aurora/Ipl1p kinase family in cell division

31 March 2020

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Aurora-kinase inhibitors as anticancer agents

31 March 2020

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The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

31 March 2020

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Mutational analysis of the phosphorylation sites of the Aie1 (Aurora-C) kinase in vitro

31 March 2020

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The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

31 March 2020

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Pak-1 expression increases with progression of colorectal carcinomas to metastasis

31 March 2020

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Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma

31 March 2020

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Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas

31 March 2020

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Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1

31 March 2020

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The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK.

31 March 2020

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The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis

31 March 2020

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The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family

31 March 2020

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CRIPak, a novel endogenous Pak1 inhibitor

31 March 2020

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A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

31 March 2020

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The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants

31 March 2020

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Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase, creatine kinase and enolase activity and isoenzymes in breast carcinoma

31 March 2020

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Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and creatine kinase activity and isoenzymes in human brain tumours

31 March 2020

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Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas

31 March 2020

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Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evalu

31 March 2020

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Induction of colonic epithelial cell apoptosis by p47-dependent oxidants

31 March 2020

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HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway

31 March 2020

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An NAD(P)H oxidase regulates growth and transcription in melanoma cells

31 March 2020

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NF-kappaB: linking inflammation and immunity to cancer development and progression

31 March 2020

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Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens

31 March 2020

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Targeted therapy against Bcl-2-related proteins in breast cancer cells

31 March 2020

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Life in the balance: how BH3-only proteins induce apoptosis.

31 March 2020

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Decreased expression of the seven ARP2/3 complex genes in human gastric cancers

31 March 2020

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Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells

31 March 2020

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Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells

31 March 2020

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Correlation of oncoprotein 18/stathmin expression in human breast cancer with established prognostic factors

31 March 2020

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Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors

31 March 2020

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Profiling of nuclear extract proteins from human neuroblastoma cell lines: the search for fingerprints.

31 March 2020

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Differentiation-stage specific expression of oncoprotein 18 in human and rat prostatic adenocarcinoma.

31 March 2020

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Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets

31 March 2020

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Role of intermediate filaments in migration, invasion and metastasis

31 March 2020

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An essential role of Pak1 phosphorylation of SHARP in Notch signaling

31 March 2020

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CtBP, an unconventional transcriptional corepressor in development and oncogenesis

31 March 2020

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A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor

31 March 2020

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