(Q42817866)

English

Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes

scientific article published on 7 March 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

author name string

Pallavi Sachdev

1

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Liyu Zeng

2

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

L H Wang

3

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

language of work or name

0 references

publication date

7 March 2002

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

277

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

17638-17648

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Rho GTPases and their effector proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rho GTPases control polarity, protrusion, and adhesion during cell movement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rho family GTPases: the cytoskeleton and beyond

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Signaling to Rho GTPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Genomic analysis of metastasis reveals an essential role for RhoC

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

A role for Rac in Tiam1-induced membrane ruffling and invasion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Differential requirement for Rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rho GTPases and signaling networks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rho GTPases are over-expressed in human tumors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Regulatory and signaling properties of the Vav family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Integrin-mediated signals regulated by members of the rho family of GTPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Signaling networks linking integrins and rho family GTPases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Integrin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Stat3 as an oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Regulation of STAT3 by direct binding to the Rac1 GTPase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

PTEN, a unique tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Vav family proteins couple to diverse cell surface receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Vav2 is an activator of Cdc42, Rac1, and RhoA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rho Family GTPases Bind to Phosphoinositide Kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Binding of Vav to Grb2 through dimerization of Src homology 3 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Novel recognition mode between Vav and Grb2 SH3 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

The insert region of Rac1 is essential for membrane ruffling but not cellular transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Vav2 is required for cell spreading

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Interplay between Rac and Rho in the control of substrate contact dynamics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111575200

21 January 2018

Identifiers

10.1074/JBC.M111575200

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

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