(Q42796101)

7 November 2017

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). (English)

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7 November 2017

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6

B A Hemmings

1 reference

7 November 2017

C C King

1

1 reference

7 November 2017

E M Gardiner

2

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7 November 2017

F T Zenke

3

1 reference

7 November 2017

B P Bohl

4

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7 November 2017

A C Newton

5

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7 November 2017

G M Bokoch

7

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7 November 2017

language of work or name

English

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publication date

1 December 2000

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Journal of Biological Chemistry

7 November 2017

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7 November 2017

275

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7 November 2017

41201-41209

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7 November 2017

52

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Emerging from the Pak: the p21-activated protein kinase family.

7 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Rho GTPases and signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Inhibition of myosin light chain kinase by p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

The Akt proto-oncogene links Ras to Pak and cell survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

A Schizosaccharomyces pombe gene, ksg1, that shows structural homology to the human phosphoinositide-dependent protein kinase PDK1, is essential for growth, mating and sporulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Determinants for substrate phosphorylation by p21-activated protein kinase (gamma-PAK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Platelet-derived growth factor (PDGF)-induced Ca2+ signaling in the CG4 oligodendroglial cell line and in transformed oligodendrocytes expressing the beta-PDGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

PDK1, one of the missing links in insulin signal transduction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

Cell Cycle- and Cln2p-Cdc28p-dependent Phosphorylation of the Yeast Ste20p Protein Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006553200

21 January 2018

Identifiers

DOI

10.1074/JBC.M006553200

1 reference

7 November 2017

1 reference