(Q51987013)

19 April 2018

title

Lats2 is an essential mitotic regulator required for the coordination of cell division. (English)

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19 April 2018

author

Daisuke Okuzaki

8

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19 April 2018

Masahito Ikawa

10

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19 April 2018

Masaru Okabe

11

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19 April 2018

Norikazu Yabuta

1

object named as

Norikazu Yabuta

1 reference

19 April 2018

Hiroshi Nojima

12

object named as

Hiroshi Nojima

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19 April 2018

author name string

Nobuhiro Okada

2

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19 April 2018

Akihiko Ito

3

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19 April 2018

Toshiya Hosomi

4

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19 April 2018

Souichi Nishihara

5

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19 April 2018

Yuya Sasayama

6

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19 April 2018

Azumi Fujimori

7

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19 April 2018

Hanjun Zhao

9

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19 April 2018

language of work or name

English

0 references

publication date

3 May 2007

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19 April 2018

Journal of Biological Chemistry

published in

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19 April 2018

volume

282

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19 April 2018

page(s)

19259-19271

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19 April 2018

issue

26

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19 April 2018

Mitotic kinases as regulators of cell division and its checkpoints

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21 January 2018

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

21 January 2018

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

21 January 2018

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

21 January 2018

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The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle

21 January 2018

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The cell-cycle-regulated budding yeast gene DBF2, encoding a putative protein kinase, has a homologue that is not under cell-cycle control

21 January 2018

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Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis

21 January 2018

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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

21 January 2018

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Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts

21 January 2018

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Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases

21 January 2018

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Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex

21 January 2018

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NDR kinases regulate essential cell processes from yeast to humans

21 January 2018

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DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein

21 January 2018

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Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates.

21 January 2018

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Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression.

21 January 2018

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Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways

21 January 2018

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Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein

21 January 2018

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NMR solution structure of Mob1, a mitotic exit network protein and its interaction with an NDR kinase peptide.

21 January 2018

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Structural and functional analysis of Saccharomyces cerevisiae Mob1.

21 January 2018

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Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

21 January 2018

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Human LATS1 is a mitotic exit network kinase

21 January 2018

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Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

21 January 2018

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

21 January 2018

1 reference

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A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

LATS1 tumor suppressor regulates G2/M transition and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

21 January 2018

1 reference

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Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M608562200

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M608562200

Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor

21 January 2018

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Lats2, a putative tumor suppressor, inhibits G1/S transition

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M608562200

Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors

21 January 2018

1 reference

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Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M608562200

Basal body/centriole assembly and continuity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M608562200

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

G1 tetraploidy checkpoint and the suppression of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

A tentative classification of centrosome abnormalities in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Polo-like kinases and the orchestration of cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

The mouse Mps1p-like kinase regulates centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Centrosome duplication: three kinases come up a winner!

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Loss of p53 and centrosome hyperamplification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Inactivation of E2F3 results in centrosome amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

A role for PML3 in centrosome duplication and genome stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Characterization of Su48, a centrosome protein essential for cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Checking out the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

The role of the polo kinase Cdc5 in controlling Cdc14 localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608562200

21 January 2018

Identifiers

DOI

10.1074/JBC.M608562200

1 reference

19 April 2018

PubMed ID

17478426

1 reference

19 April 2018