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Aneuploidy and cancer
scientific article published in Nature
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instance of
scholarly article
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review article
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stated in
Europe PubMed Central
title
Aneuploidy and cancer
(English)
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author name string
Harith Rajagopalan
series ordinal
1
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Christoph Lengauer
series ordinal
2
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language of work or name
English
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publication date
November 2004
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published in
Nature
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volume
432
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page(s)
338-341
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issue
7015
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exact match
https://scigraph.springernature.com/pub.10.1038/nature03099
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cites work
The clonal evolution of tumor cell populations
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A genetic model for colorectal tumorigenesis
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Two genetic hits (more or less) to cancer
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The role of chromosomal instability in tumor initiation
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Genetic instabilities in human cancers
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Chromosomal instability and cytoskeletal defects in oral cancer cells
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Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres
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Breast cancer genetic evolution: I. Data from cytogenetics and DNA content
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Barrett's esophagus. Correlation between flow cytometry and histology in detection of patients at risk for adenocarcinoma
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Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer.
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The shortest telomeres drive karyotype evolution in transformed cells
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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells
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Centrosome amplification drives chromosomal instability in breast tumor development
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Hereditary colorectal cancer
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Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives.
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Deficient DNA mismatch repair: a common etiologic factor for colon cancer
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Gastrointestinal cancer of the microsatellite mutator phenotype pathway
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Genetic instability in colorectal cancers
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Mutations of mitotic checkpoint genes in human cancers
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Aneuploid colon cancer cells have a robust spindle checkpoint
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A new view of the spindle checkpoint
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Assembly of kinetochores in vertebrate cells
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Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
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The significance of unstable chromosomes in colorectal cancer.
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Carcinogen-specific induction of genetic instability.
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Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
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Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.
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MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
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MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
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Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.
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Three classes of genes mutated in colorectal cancers with chromosomal instability.
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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
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Inactivation of hCDC4 can cause chromosomal instability
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Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer
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Mitotic stability of yeast chromosomes: a colony color assay that measures nondisjunction and chromosome loss
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Counting alleles to predict recurrence of early-stage colorectal cancers
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Molecular predictors of survival after adjuvant chemotherapy for colon cancer
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Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients
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Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.
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Identifiers
DOI
10.1038/NATURE03099
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Dimensions Publication ID
1012218108
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PubMed ID
15549096
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ResearchGate publication ID
8178335
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