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A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy
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scholarly article
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stated in
PubMed
review article
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stated in
Europe PubMed Central
title
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy
(English)
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stated in
PubMed
main subject
immunotherapy
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based on heuristic
inferred from title
author name string
Robert D. Leone
series ordinal
1
1 reference
stated in
Crossref
Ying-Chun Lo
series ordinal
2
1 reference
stated in
Crossref
Jonathan D. Powell
series ordinal
3
1 reference
stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
8 April 2015
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stated in
PubMed
published in
Computational and Structural Biotechnology Journal
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stated in
Crossref
volume
13
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stated in
PubMed
page(s)
265-72
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stated in
PubMed
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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
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CTLA-4 control over Foxp3+ regulatory T cell function
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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
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Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses
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Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model
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Requirement of NK cells for selective A2A receptor blockade to suppress CD73+ tumor metastasis
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Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
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Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial
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Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs
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Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors
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Adenosine A2B receptor blockade slows growth of bladder and breast tumors
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Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
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Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis.
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Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease
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29 September 2017
Adenosine receptor subtypes: characterization and therapeutic regulation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
retrieved
29 September 2017
Role of extracellular ATP and P1 and P2 classes of purinergic receptors in T-cell development and cytotoxic T lymphocyte effector functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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29 September 2017
CTLA-4 is a second receptor for the B cell activation antigen B7
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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29 September 2017
The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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2 June 2018
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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2 June 2018
Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
retrieved
2 June 2018
Effects of extracellular ATP and adenosine on different thymocyte subsets: possible role of ATP-gated channels and G protein-coupled purinergic receptor
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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2 June 2018
Ecto-ATPase activity in cytolytic T-lymphocytes. Protection from the cytolytic effects of extracellular ATP.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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2 June 2018
Trial Watch: Chemotherapy with immunogenic cell death inducers.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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20 June 2018
Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors.
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PubMed Central
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27 November 2018
Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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27 November 2018
Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells
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27 November 2018
B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4415113
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27 November 2018
Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages
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PubMed Central
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27 November 2018
Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Apparent involvement of the A(2A) subtype adenosine receptor in the anti-inflammatory interactions of CGS 21680, cyclopentyladenosine, and IB-MECA with human neutrophils
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25941561
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25941561
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Two novel families of ectonucleotidases: molecular structures, catalytic properties and a search for function
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25941561
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25941561
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CSBJ.2015.03.008
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4221062
OpenCitations bibliographic resource ID
4221062
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4221062
PMCID
4415113
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4221062
PubMed ID
25941561
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4221062
ResearchGate publication ID
274737018
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