(Q34572202)

3 August 2017

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title

T-cell regulation by CD28 and CTLA-4. (English)

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3 August 2017

M L Alegre

1

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3 August 2017

K A Frauwirth

series ordinal

2

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3 August 2017

C B Thompson

series ordinal

3

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3 August 2017

1 December 2001

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Nature Reviews Immunology

3 August 2017

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3 August 2017

1

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3 August 2017

220-228

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3 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/35105024

3 August 2017

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cites work

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

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Antigen decoding by T lymphocytes: from synapses to fate determination

21 January 2018

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The duration of antigenic stimulation determines the fate of naive and effector T cells.

21 January 2018

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CD28/B7 system of T cell costimulation

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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T cell activation determined by T cell receptor number and tunable thresholds.

21 January 2018

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Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

21 January 2018

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p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

21 January 2018

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Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

21 January 2018

1 reference

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

21 January 2018

1 reference

T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

21 January 2018

1 reference

The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

21 January 2018

1 reference

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

21 January 2018

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CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation

21 January 2018

1 reference

Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation

21 January 2018

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Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

21 January 2018

1 reference

A point mutation in CD28 distinguishes proliferative signals from survival signals

21 January 2018

1 reference

Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo

21 January 2018

1 reference

Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.

21 January 2018

1 reference

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

21 January 2018

1 reference

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

21 January 2018

1 reference

Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation

21 January 2018

1 reference

Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling

21 January 2018

1 reference

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

21 January 2018

1 reference

A new member of the immunoglobulin superfamily--CTLA-4

21 January 2018

1 reference

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

21 January 2018

1 reference

KIR expression on self-reactive CD8+ T cells is controlled by T-cell receptor engagement

21 January 2018

1 reference

Structure of murine CTLA-4 and its role in modulating T cell responsiveness

21 January 2018

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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

21 January 2018

1 reference

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

21 January 2018

1 reference

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

21 January 2018

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

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CTLA-4 can function as a negative regulator of T cell activation

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

1 reference

Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice

21 January 2018

1 reference

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses

21 January 2018

1 reference

Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

21 January 2018

1 reference

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

21 January 2018

1 reference

Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase

21 January 2018

1 reference

Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

21 January 2018

1 reference

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

1 reference

Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

21 January 2018

1 reference

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

21 January 2018

1 reference

A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood

21 January 2018

1 reference

Induction of T cell anergy in the absence of CTLA-4/B7 interaction

21 January 2018

1 reference

CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo.

21 January 2018

1 reference

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance.

21 January 2018

1 reference

B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.

21 January 2018

1 reference

Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.

21 January 2018

1 reference

Structural analysis of CTLA-4 function in vivo

21 January 2018

1 reference

Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation

21 January 2018

1 reference

Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

21 January 2018

1 reference

Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.

21 January 2018

1 reference

Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail

21 January 2018

1 reference

Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition

21 January 2018

1 reference

Molecular basis of T cell inactivation by CTLA-4

21 January 2018

1 reference

Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

21 January 2018

1 reference

c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

21 January 2018

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Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

21 January 2018

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JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

21 January 2018

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JNK is required for effector T-cell function but not for T-cell activation

21 January 2018

1 reference

Defective T Cell Differentiation in the Absence of Jnk1

21 January 2018

1 reference

Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

21 January 2018

2 references

21 January 2018

7 January 2021

A new analysis of allogeneic interactions

1 reference

7 January 2021

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

1 reference

7 January 2021

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

7 January 2021

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

1 reference

7 January 2021

T lymphocyte costimulation mediated by reorganization of membrane microdomains

1 reference

7 January 2021

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

1 reference

7 January 2021

CD4+CD25high regulatory cells in human peripheral blood

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7 January 2021

CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression

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7 January 2021

Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4

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7 January 2021

The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation

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7 January 2021

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

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7 January 2021

CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts

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7 January 2021

CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells

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7 January 2021

Identifiers

DOI

10.1038/35105024

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Dimensions Publication ID

3 August 2017

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