(Q28118071)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase (English)

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

GOA release 2020-03-11

ALK and LTK ligand 1

1 reference

positive regulation of ERK5 cascade

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Jikui Guan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Georg Wolfstetter

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Patricia Mendoza

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Fredrik Hugosson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Ruth Palmer

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

author name string

Ganesh Umapathy

2

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Yasuo Yamazaki

3

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Kathrin Pfeifer

6

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Ateequrrahman Mohammed

7

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Hongbing Zhang

9

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Robert Halenbeck

11

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Bengt Hallberg

12

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Amy W Hsu

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

language of work or name

English

0 references

publication date

29 September 2015

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

volume

4

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

page(s)

e09811

2 references

4 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

25 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Identification of ALK as a major familial neuroblastoma predisposition gene

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Activating mutations in ALK provide a therapeutic target in neuroblastoma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Oncogenic mutations of ALK kinase in neuroblastoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

The neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4658194

Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.

2 June 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(mili(Alk)) as receptor for Jeb signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.09811

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26418745

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.09811

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26418745%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

2 references