(Q28131779)

8

object named as

Dennis J Selkoe

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author name string

Dominic M Walsh

1

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Igor Klyubin

2

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Julia V Fadeeva

3

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William K Cullen

4

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Roger Anwyl

5

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Michael S Wolfe

Alzheimer's disease: genes, proteins, and therapy

6

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language of work or name

English

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publication date

4 April 2002

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published in

Nature

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volume

416

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issue

6880

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page(s)

535-9

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cites work

1 reference

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In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

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Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

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Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo.

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

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Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

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A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

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Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

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Amyloid fibrillogenesis: themes and variations

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Designing conditions for in vitro formation of amyloid protofilaments and fibrils

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Functional human insulin-degrading enzyme can be expressed in bacteria

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Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere

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