(Q28140629)

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Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA

scientific article (publication date: 16 June 2000)

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10748052%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10748052%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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5 November 2019

author name string

MacDonald JI

1

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5 November 2019

Gryz EA

2

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5 November 2019

Kubu CJ

3

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5 November 2019

Verdi JM

4

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5 November 2019

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publication date

1 June 2000

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5 November 2019

Journal of Biological Chemistry

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5 November 2019

275

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5 November 2019

18225-18233

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5 November 2019

24

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5 November 2019

Signal transduction by the neurotrophin receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Identification and characterization of novel substrates of Trk receptors in developing neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1 reference

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21 January 2018

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

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21 January 2018

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Grb2 binding to the different isoforms of Ret tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

SH2 and SH3 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Dimerization of cell surface receptors in signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Identification of the APS protein as a novel insulin receptor substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

A new function for phospholipase C-gamma1: coupling to the adaptor protein GRB2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

CMS: an adapter molecule involved in cytoskeletal rearrangements

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Deletions in the extracellular domain of rat trkA lead to an altered differentiative phenotype in neurotrophin responsive cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

A novel juxtamembrane deletion in rat TrkA blocks differentiative but not mitogenic cell signaling in response to nerve growth factor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Nonphosphorylated peptide ligands for the Grb2 Src homology 2 domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

A kinase insert isoform of rat TrkA supports nerve growth factor-dependent cell survival but not neurite outgrowth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

SH2-B is required for nerve growth factor-induced neuronal differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M001862200

21 January 2018

Identifiers

10.1074/JBC.M001862200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10748052%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10748052%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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