(Q28141116)

1

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N Domae

2

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N Nagan

3

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Y A Hannun

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

31 December 1999

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published in

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volume

274

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issue

53

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page(s)

38131-9

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cites work

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Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity

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Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

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Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

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Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

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Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

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Role for ceramide in cell cycle arrest.

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Acid sphingomyelinase from human urine: purification and characterization.

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Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain

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Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

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Alkaline sphingomyelinase activity in rat gastrointestinal tract: distribution and characteristics

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Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)

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Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

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Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

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CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase.

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Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?

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Growth-dependent accumulation of monoalkylglycerol in Madin-Darby canine kidney cells. Evidence for a role in the regulation of protein kinase C.

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?

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Specificity of lysophospholipase D.

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Platelet-activating factor and its analogs: metabolic pathways and related intracellular processes

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The inhibition of cell signaling pathways by antitumor ether lipids

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