(Q28188547)

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Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells

scientific article (publication date: 12 February 2004)

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Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells (English)

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apoptotic process

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hepatocellular carcinoma

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inferred from title

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author name string

Xiaoling Zhou

1

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Snorri S Thorgeirsson

2

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Nicholas C Popescu

3

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language of work or name

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publication date

12 February 2004

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23

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6

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1308-13

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Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma

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Rho GTPases in transformation and metastasis.

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Loss of heterozygosity of chromosome 8p and 11p in the dysplastic nodule and hepatocellular carcinoma.

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Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines

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Chromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compared

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Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho.

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StAR-related Lipid Transfer (START) Proteins: Mediators of Intracellular Lipid Metabolism

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The role of Rho GTPases in disease development

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BCL-2 family members and the mitochondria in apoptosis

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Establishment and characterization of a new human hepatocellular carcinoma cell line

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A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities

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BH3-Only proteins-essential initiators of apoptotic cell death

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A multigenic program mediating breast cancer metastasis to bone

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Rho GTPase-activating proteins in cell regulation

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships

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START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins

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Molecular pathogenesis of human hepatocellular carcinoma

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Sequence variants ofDLC1 in colorectal and ovarian tumours

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Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers

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DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity

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Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization

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