(Q28207928)

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Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer

scientific article (publication date: 2002)

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Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer (English)

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inflammatory breast cancer

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author name string

Kenneth L van Golen

1

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Li Wei Bao

2

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Quintin Pan

3

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Fred R Miller

4

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Zhi Fen Wu

5

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Sofia D Merajver

6

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Kenneth L. van Golen

1

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Fred R. Miller

4

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Sofia D. Merajver

6

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language of work or name

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publication date

2002

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Clinical & Experimental Metastasis

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19

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4

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301-11

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301-311

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Human breast cancer cell lines as models of growth regulation and disease progression

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https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and function of phosphoinositide 3-kinases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic analysis of metastasis reveals an essential role for RhoC

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phagokinetic tracks of 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effectors for the Rho GTPases

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https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeleton cross-talk during cell motility.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen-activated protein kinase kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 8 expression regulates tumorigenicity and metastases in androgen-independent prostate cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New aspects of integrin signaling in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammographic appearance of recurrent breast carcinoma in six patients with TRAM flap breast reconstructions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

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Membrane ruffling and signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho family members: Activators of MAP kinase cascades

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory breast cancer: the experience of the surveillance, epidemiology, and end results (SEER) program

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of kinase inhibitors to dissect signaling pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho GTPases and their effector proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic fibroblast growth factor in human melanoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho GTPases and the actin cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho proteins: targets for bacterial toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras superfamily.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GTP-binding protein Rho.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predominance of the metastatic phenotype in hybrids formed by fusion of mouse and human melanoma clones

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous production of interleukin-8 by human lung cancer cells and its augmentation by tumor necrosis factor alpha and interleukin-1 at protein and mRNA levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small GTP-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes. Apparent involvement of phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory breast cancer: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small GTP-binding proteins and the regulation of the actin cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12090470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1023/A:1015518114931

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