(Q52532836)

2 May 2018

review article

1 reference

title

Structure and function of phosphoinositide 3-kinases. (English)

1 reference

2 May 2018

author

Matthias P Wymann

series ordinal

1

1 reference

2 May 2018

Luciano Pirola

series ordinal

2

1 reference

2 May 2018

publication date

1 December 1998

1 reference

2 May 2018

Biochimica et Biophysica Acta

published in

1 reference

2 May 2018

volume

1436

1 reference

2 May 2018

issue

1-2

1 reference

2 May 2018

page(s)

127-150

1 reference

2 May 2018

Inositol trisphosphate, a novel second messenger in cellular signal transduction

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

7 January 2021

Phospholipid signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The elemental principles of calcium signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Oncogenes and signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol kinase activity associates with viral p60src protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structural and functional diversity of phosphoinositide 3-kinases.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Using structure to define the function of phosphoinositide 3-kinase family members

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphoinositide 3-kinases: a conserved family of signal transducers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Signalling through the lipid products of phosphoinositide-3-OH kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Inositol lipid pathways turn turtle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphoinositides as regulators in membrane traffic

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

When is a lipid kinase not a lipid kinase? When it is a protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Control of p70 s6 kinase by kinase activity of FRAP in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The Schizosaccharomyces pombe rad3 checkpoint gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cell-cycle signaling: Atm displays its many talents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structure of the PI3K SH3 domain and analysis of the SH3 family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Crystal structure of P13K SH3 domain at 20 angstroms resolution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Modular binding domains in signal transduction proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structural basis for the binding of proline-rich peptides to SH3 domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Identification of amino acid residues required for a specific interaction between Src-tyrosine kinase and proline-rich region of phosphatidylinositol-3' kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Recognition and specificity in protein tyrosine kinase-mediated signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Bcr encodes a GTPase-activating protein for p21rac

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Rho Family GTPases Bind to Phosphoinositide Kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

p110δ, a novel phosphoinositide 3-kinase in leukocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Tyrosine 508 of the 85-kilodalton subunit of phosphatidylinositol 3-kinase is phosphorylated by the platelet-derived growth factor receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The GTPase dynamin binds to and is activated by a subset of SH3 domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Profilin and gelsolin stimulate phosphatidylinositol 3-kinase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Some unique characteristics of thylakoid unisite ATPase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol-3-OH kinase as a direct target of Ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of PI 3-kinase by G protein betagamma subunits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Calmodulin activates phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structural framework for the protein kinase family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A template for the protein kinase family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Crystal structure of the tyrosine kinase domain of the human insulin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Autoregulatory mechanisms in protein-tyrosine kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Inositide signalling in Chlamydomonas: characterization of a phosphatidylinositol 3-kinase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The activation of phosphatidylinositol 3-kinase by Ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structural analysis of a novel isoform of phosphoinositide 3OH-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A mammalian scaffold complex that selectively mediates MAP kinase activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Association of p21ras with phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

7 January 2021

The hunt for Ras targets

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Interaction of Ras with phosphoinositide 3-kinase gamma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Chemotactic peptide-induced activation of Ras in human neutrophils is associated with inhibition of p120-GAP activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The IRS-signalling system during insulin and cytokine action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structure-function relationships in Src family and related protein tyrosine kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Jaks and STATs: biological implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

PI 3-kinase: a pivotal pathway in T-cell activation?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

FYVE fingers bind PtdIns(3)P

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A functional PtdIns(3)P-binding motif

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Vesicular transport. Sticky fingers grab a lipid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 alpha subunit. Implications for the endocytic pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Inositol lipid 5-phosphatases--traffic signals and signal traffic.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Pleckstrin homology domains: a common fold with diverse functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The pleckstrin homology domain: an intriguing multifunctional protein module

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Role of translocation in the activation and function of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Mechanism of activation of protein kinase B by insulin and IGF-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

p70s6k function is essential for G1 progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphorylation and activation of p70s6k by PDK1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

p70 S6 kinase: an enigma with variations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

TOR signalling and control of cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Lymphocyte signalling: a coordinating role for Vav?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The biochemical basis of the NADPH oxidase of phagocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structural and mechanistic features of phospholipases C: effectors of inositol phospholipid-mediated signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

SHIP modulates immune receptor responses by regulating membrane association of Btk.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Worm longevity gene cloned

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

7 January 2021

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Structure of Type IIβ Phosphatidylinositol Phosphate Kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Selective recognition of phosphatidylinositol 3,4,5-trisphosphate by a synthetic peptide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Activation of phosphatidylinositol 3-kinase by insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

B61 is a ligand for the ECK receptor protein-tyrosine kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells--signals emanating from the erythropoietin receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Regulating integrin-mediated adhesion: one more function for PI 3-kinase?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Signal transduction in neutrophil activation. Phosphatidylinositol 3-kinase is stimulated without tyrosine phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Wortmannin-sensitive activation of p70s6k by endogenous and heterologously expressed Gi-coupled receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

Receptor protein-tyrosine kinases and their signal transduction pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2898%2900139-8

10.1016/S0005-2760(98)00139-8

7 January 2021

Identifiers

DOI

1 reference

2 May 2018

1 reference

2 May 2018