(Q28211612)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14570896%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism (English)

1 reference

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20 December 2019

3

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20 December 2019

Christopher L Karp

6

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20 December 2019

author name string

Magnus Otto

1

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20 December 2019

Heiko Hawlisch

2

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20 December 2019

Melanie Müller

4

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20 December 2019

Andreas Klos

5

1 reference

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20 December 2019

Jörg Köhl

7

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20 December 2019

language of work or name

English

0 references

publication date

21 October 2003

1 reference

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Journal of Biological Chemistry

20 December 2019

published in

1 reference

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20 December 2019

volume

279

1 reference

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20 December 2019

issue

1

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20 December 2019

page(s)

142-151

1 reference

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Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities.

20 December 2019

cites work

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The C5a receptor is expressed by human renal proximal tubular epithelial cells

21 January 2018

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Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma

21 January 2018

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The chemotactic receptor for human C5a anaphylatoxin

21 January 2018

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Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

21 January 2018

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G-protein-coupled receptors and signaling networks: emerging paradigms.

21 January 2018

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Arthritis critically dependent on innate immune system players

21 January 2018

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A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells

21 January 2018

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Identification of four novel human G protein-coupled receptors expressed in the brain

21 January 2018

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The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)

21 January 2018

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C5L2, a nonsignaling C5A binding protein

21 January 2018

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Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a.

21 January 2018

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Pharmacological characterization of antagonists of the C5a receptor

21 January 2018

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Identification of a potent and orally active non-peptide C5a receptor antagonist

21 January 2018

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A detailed analysis of the C5a anaphylatoxin effector domain: selection of C5a phage libraries on differentiated U937 cells

21 January 2018

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A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats

21 January 2018

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A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats

21 January 2018

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Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils.

21 January 2018

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Detection of native human complement components C3 and C5 and their primary activation peptides C3a and C5a (anaphylatoxic peptides) by ELISAs with monoclonal antibodies.

21 January 2018

1 reference

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The C terminus of the human C5a receptor (CD88) is required for normal ligand-dependent receptor internalization

21 January 2018

1 reference

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A selection system to study C5a-C5a-receptor interactions: phage display of a novel C5a anaphylatoxin, Fos-C5aAla27.

21 January 2018

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Molecular epitope identification by limited proteolysis of an immobilized antigen-antibody complex and mass spectrometric peptide mapping

21 January 2018

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The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310078200

Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids

21 January 2018

1 reference

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Improvements in the minimum binding sequence of C5a: examination of His-67

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310078200

Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310078200

Evaluation of the C-terminal C5a effector site with short synthetic C5a analog peptides

21 January 2018

1 reference

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C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor

21 January 2018

1 reference

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The pharmacophore of the human C5a anaphylatoxin

21 January 2018

1 reference

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Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310078200

Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor. Arg2O6 determines high-affinity binding sites of C5a receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310078200

Chimeric receptors of the human C3a receptor and C5a receptor (CD88)

21 January 2018

1 reference

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Mapping the ligand-binding site on the C5a receptor: arginine74 of C5a contacts aspartate282 of the C5a receptor

21 January 2018

1 reference

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Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.

21 January 2018

1 reference

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C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway

21 January 2018

1 reference

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Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3.

21 January 2018

1 reference

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A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration.

21 January 2018

1 reference

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Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N.

21 January 2018

1 reference

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The human mast cell line HMC-1 expresses C5a receptors and responds to C5a but not to C5a(desArg).

21 January 2018

1 reference

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The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells

21 January 2018

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Expression and function of C5a receptor in mouse microvascular endothelial cells

21 January 2018

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Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils

21 January 2018

1 reference

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Neurogenic amplification of immune complex inflammation

21 January 2018

1 reference

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Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment

21 January 2018

1 reference

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A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction

21 January 2018

1 reference

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Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

21 January 2018

1 reference

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Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung

21 January 2018

1 reference

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IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migration in vivo.

21 January 2018

1 reference

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Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding

21 January 2018

1 reference

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Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310078200

Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310078200

21 January 2018

Identifiers

DOI

10.1074/JBC.M310078200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14570896%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference