(Q28241366)

English

High affinity radiopharmaceuticals based upon lansoprazole for PET imaging of aggregated tau in Alzheimer's disease and progressive supranuclear palsy: synthesis, preclinical evaluation, and lead selection

scientific article (publication date: 20 August 2014)

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scholarly article

1 reference

Europe PubMed Central

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19 March 2020

High affinity radiopharmaceuticals based upon lansoprazole for PET imaging of aggregated tau in Alzheimer's disease and progressive supranuclear palsy: synthesis, preclinical evaluation, and lead selection (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896980%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

0 references

Alzheimer's disease

1 reference

based on heuristic

inferred from title

progressive supranuclear palsy

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

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19 March 2020

Peter J. H. Scott

13

1 reference

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19 March 2020

author name string

Maria V Fawaz

1

1 reference

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19 March 2020

Melissa E Rodnick

3

1 reference

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19 March 2020

Garrett M Carpenter

4

1 reference

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19 March 2020

Xia Shao

5

1 reference

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19 March 2020

Timothy J Desmond

6

1 reference

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19 March 2020

Phillip Sherman

7

1 reference

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19 March 2020

Carole A Quesada

8

1 reference

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19 March 2020

Brian G Hockley

9

1 reference

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19 March 2020

Michael R Kilbourn

10

1 reference

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19 March 2020

Roger L Albin

11

1 reference

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19 March 2020

Kirk A Frey

12

1 reference

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19 March 2020

language of work or name

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publication date

16 June 2014

1 reference

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19 March 2020

ACS Chemical Neuroscience

1 reference

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19 March 2020

5

1 reference

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19 March 2020

8

1 reference

Europe PubMed Central

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19 March 2020

718-730

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896980%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

20 March 2017

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

6 April 2017

Evaluation of [(11)C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

PET imaging of neuropathology in tauopathies: progressive supranuclear palsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

A highly selective and specific PET tracer for imaging of tau pathologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Research towards tau imaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Florbetaben to trace amyloid-β in the Alzheimer brain by means of PET.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

In vivo brain imaging of tangle burden in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Lansoprazole: pharmacokinetics, pharmacodynamics and clinical uses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

The mechanism of action of multidrug-resistance-linked P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

Clinical pharmacokinetics of lansoprazole.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

29 September 2017

[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

2 June 2018

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

2 June 2018

Identification of the human P450 enzymes involved in lansoprazole metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

2 June 2018

Oxidative metabolism of lansoprazole by human liver cytochromes P450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

2 June 2018

[18F]Flutemetamol amyloid-beta PET imaging compared with [11C]PIB across the spectrum of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Pharmacokinetics of lansoprazole and its main metabolites after single and multiple intravenous doses in healthy Chinese subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Selectivity requirements for diagnostic imaging of neurofibrillary lesions in Alzheimer's disease: a simulation study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

PET of brain amyloid and tau in mild cognitive impairment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Stereoselective metabolism of lansoprazole by human liver cytochrome P450 enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140593

27 November 2018

Discussion of targeting proteins in vivo: in vitro guidelines

1 reference

https://pubmed.ncbi.nlm.nih.gov/24896980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lansoprazole pharmacokinetics in subjects with various degrees of kidney function

1 reference

https://pubmed.ncbi.nlm.nih.gov/24896980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24896980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/CN500103U

1 reference

Europe PubMed Central

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19 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896980%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24896980%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

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