(Q34502453)

2 August 2017

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title

The mechanism of action of multidrug-resistance-linked P-glycoprotein (English)

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2 August 2017

multiple drug resistance

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Sauna ZE

1

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2 August 2017

Smith MM

2

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2 August 2017

Müller M

3

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2 August 2017

Kerr KM

4

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2 August 2017

Ambudkar SV

5

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2 August 2017

1 December 2001

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Journal of Bioenergetics and Biomembranes

2 August 2017

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2 August 2017

33

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2 August 2017

481-491

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2 August 2017

6

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https://scigraph.springernature.com/pub.10.1023/a:1012875105006

2 August 2017

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cites work

Expression of P-glycoprotein, a multidrug-resistance gene product, is induced by radiotherapy in patients with oral squamous cell carcinoma.

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12 December 2020

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

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12 December 2020

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.

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12 December 2020

Characterization of the azidopine and vinblastine binding site of P-glycoprotein

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12 December 2020

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance

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12 December 2020

Inhibition of P-glycoprotein ATPase activity by beryllium fluoride

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12 December 2020

Catalytic mechanism of P-glycoprotein.

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12 December 2020

Both P-glycoprotein nucleotide-binding sites are catalytically active

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12 December 2020

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

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12 December 2020

Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance.

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12 December 2020

The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice.

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12 December 2020

The physiological function of drug-transporting P-glycoproteins

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12 December 2020

Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains

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12 December 2020

Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study

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12 December 2020

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

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12 December 2020

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance

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12 December 2020

Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates

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12 December 2020

Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

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12 December 2020

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12.

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12 December 2020

Drug-stimulated ATPase activity of the human P-glycoprotein.

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12 December 2020

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

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12 December 2020

Genetic analysis of the multidrug transporter

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12 December 2020

ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells.

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12 December 2020

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

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12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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12 December 2020

Both ATP sites of human P-glycoprotein are essential but not symmetric

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12 December 2020

Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

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12 December 2020

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

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12 December 2020

What have we learnt thus far from mice with disrupted P-glycoprotein genes?

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12 December 2020

Genetic dissection of the function of mammalian P-glycoproteins

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12 December 2020

Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies

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12 December 2020

Localization of the iodomycin binding site in hamster P-glycoprotein

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12 December 2020

Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein

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12 December 2020

The catalytic cycle of P-glycoprotein

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12 December 2020

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

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12 December 2020

Is the multidrug transporter a flippase?

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12 December 2020

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

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12 December 2020

Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters

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12 December 2020

Multidrug resistance: a solvable problem?

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12 December 2020

P-glycoprotein--a mediator of multidrug resistance in tumour cells

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12 December 2020

Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP.

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12 December 2020

A multidrug resistance transporter from human MCF-7 breast cancer cells

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12 December 2020

The role of the MDR protein in altered drug translocation across tumor cell membranes

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12 December 2020

Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain

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12 December 2020

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12 December 2020

Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.

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12 December 2020

Pharmacology of drugs that alter multidrug resistance in cancer

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12 December 2020

Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells

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12 December 2020

Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.

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12 December 2020

X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution

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12 December 2020

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

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12 December 2020

A general pattern for substrate recognition by P-glycoprotein.

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12 December 2020

Covalent inhibitors of P-glycoprotein ATPase activity

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12 December 2020

ATPase activity of Chinese hamster P-glycoprotein

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12 December 2020

Energy coupling to periplasmic binding protein-dependent transport systems: stoichiometry of ATP hydrolysis during transport in vivo

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12 December 2020

Functional expression of P-glycoproteins in secretory vesicles.

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12 December 2020

GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells

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12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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12 December 2020

How does P-glycoprotein recognize its substrates?

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12 December 2020

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

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12 December 2020

Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

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12 December 2020

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase

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12 December 2020

P-glycoprotein expression as unfavorable prognostic factor in acute myeloid leukemia.

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12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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12 December 2020

Biology of the multidrug resistance-associated protein, MRP.

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12 December 2020

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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12 December 2020

The biochemistry of P-glycoprotein-mediated multidrug resistance

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12 December 2020

Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein

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12 December 2020

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

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12 December 2020

Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis

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12 December 2020

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

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12 December 2020

Multidrug resistance transporters and modulation

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12 December 2020

The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

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12 December 2020

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein

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12 December 2020

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

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12 December 2020

Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin

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12 December 2020

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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12 December 2020

Complete characterization of the human ABC gene family.

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12 December 2020

Exploiting multidrug resistance to treat cancer.

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12 December 2020

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes

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12 December 2020

Characterization of the adenosine triphosphatase activity of the periplasmic histidine permease, a traffic ATPase (ABC transporter).

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12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system

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12 December 2020

Multidrug resistance in lymphomas.

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12 December 2020

Value of P-glycoprotein, glutathione S-transferase pi, c-erbB-2, and p53 as prognostic factors in ovarian carcinomas

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12 December 2020

The P-glycoprotein efflux pump: how does it transport drugs?

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12 December 2020

Reconstitution of drug transport by purified P-glycoprotein

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12 December 2020

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

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12 December 2020

Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump

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12 December 2020

Identifiers

DOI

10.1023/A:1012875105006

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Dimensions Publication ID

2 August 2017

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