(Q33784443)

29 July 2017

1 reference

title

Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies (English)

1 reference

29 July 2017

F J Sharom

1

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29 July 2017

R Liu

series ordinal

2

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29 July 2017

Y Romsicki

series ordinal

3

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29 July 2017

P Lu

series ordinal

4

1 reference

29 July 2017

language of work or name

English

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publication date

1 December 1999

1 reference

Biochimica et Biophysica Acta

29 July 2017

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29 July 2017

1461

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29 July 2017

2

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29 July 2017

327-345

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P-glycoprotein--a mediator of multidrug resistance in tumour cells

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

The P-glycoprotein efflux pump: how does it transport drugs?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

ABC Transporters: From Microorganisms to Man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

ATP-dependent transport systems in bacteria and humans: relevance to cystic fibrosis and multidrug resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

The ABC family of multidrug transporters in microorganisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Diagnosis and reversal of multidrug resistance in paediatric cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Crystal structure of the ATP-binding subunit of an ABC transporter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

The catalytic cycle of P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Pleiotropic phenotype of colchicine-resistant CHO cells: cross-resistance and collateral sensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Efficient purification and reconstitution of P-glycoprotein for functional and structural studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Purification of functional human P-glycoprotein expressed in Saccharomyces cerevisiae.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Reconstitution of drug transport by purified P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Membrane topology of a cysteine-less mutant of human P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

A new structural model for P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Structural model of the nucleotide-binding conserved component of periplasmic permeases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Sequence homologies between nucleotide binding regions of CFTR and G-proteins suggest structural and functional similarities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

A novel model for the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Cloning, overexpression, purification, and characterization of the carboxyl-terminal nucleotide binding domain of P-glycoprotein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Secondary structure of P-glycoprotein investigated by circular dichroism and amino acid sequence analysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Secondary and tertiary structure changes of reconstituted P-glycoprotein. A Fourier transform attenuated total reflection infrared spectroscopy analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Trinitrophenyl-ATP binding to the ArsA protein: the catalytic subunit of an anion pump.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Expression and functional properties of the second predicted nucleotide binding fold of the cystic fibrosis transmembrane conductance regulator fused to glutathione-S-transferase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Recombinant N-terminal nucleotide-binding domain from mouse P-glycoprotein. Overexpression, purification, and role of cysteine 430

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein in close proximity to the ATP site.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Fluorescence studies on the nucleotide binding domains of the P-glycoprotein multidrug transporter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Interaction of P-glycoprotein with defined phospholipid bilayers: a differential scanning calorimetric study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

The ATPase and ATP-binding functions of P-glycoprotein--modulation by interaction with defined phospholipids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Proximity of the nucleotide binding domains of the P-glycoprotein multidrug transporter to the membrane surface: a resonance energy transfer study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Is the multidrug transporter a flippase?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Allosteric regulation of [3H]vinblastine binding to P-glycoprotein of MCF-7 ADR cells by dexniguldipine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Radioligand-binding assay employing P-glycoprotein-overexpressing cells: testing drug affinities to the secretory intestinal multidrug transporter.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Linear and cyclic peptides as substrates and modulators of P-glycoprotein: peptide binding and effects on drug transport and accumulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Calcein accumulation as a fluorometric functional assay of the multidrug transporter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Efficiency of P-glycoprotein-mediated exclusion of rhodamine dyes from multidrug-resistant cells is determined by their passive transmembrane movement rate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Energetics and mechanism of drug transport mediated by the lactococcal multidrug transporter LmrP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Structural aspects of the Ca(2+)-ATPase from sarcoplasmic reticulum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2899%2900166-2

10.1016/S0005-2736(99)00166-2

7 January 2021

Identifiers

DOI

1 reference

29 July 2017

1 reference