(Q28249276)

title

Branched-chain amino acids in metabolic signalling and insulin resistance (English)

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Christopher J Lynch

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Endocrinology

4 June 2020

language of work or name

English

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publication date

December 2014

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published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

723-736

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json

Interplay between lipids and branched-chain amino acids in development of insulin resistance

4 June 2020

cites work

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20 March 2017

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Regulation of the branched-chain alpha-ketoacid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease

20 March 2017

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Molecular defects in the E1 alpha subunit of the branched-chain alpha-ketoacid dehydrogenase complex that cause maple syrup urine disease

20 March 2017

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On the mechanisms of the formation of L-alloisoleucine and the 2-hydroxy-3-methylvaleric acid stereoisomers from L-isoleucine in maple syrup urine disease patients and in normal humans

20 March 2017

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Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women

20 March 2017

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20 March 2017

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20 March 2017

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Leucine improves glucose and lipid status in offspring from obese dams, dependent on diet type, but not caloric intake

20 March 2017

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Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting

20 March 2017

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Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

20 March 2017

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Effect of dietary protein on the liver content and subunit composition of the branched-chain alpha-ketoacid dehydrogenase complex

20 March 2017

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Metabolite profiles and the risk of developing diabetes

20 March 2017

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

7 April 2017

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7 April 2017

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Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Alloisoleucine differentiates the branched-chain aminoacidemia of Zucker and dietary obese rats

29 September 2017

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Effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis

29 September 2017

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Adipose transplant for inborn errors of branched chain amino acid metabolism in mice

29 September 2017

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High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner

29 September 2017

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Disrupting rhythms: diet-induced obesity impairs diurnal rhythms in metabolic tissues

29 September 2017

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Regulation of mTORC1 and its impact on gene expression at a glance

29 September 2017

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Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.

29 September 2017

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Oxidative stress and protein carbonylation in adipose tissue - implications for insulin resistance and diabetes mellitus

29 September 2017

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Leucine and protein metabolism in obese Zucker rats

29 September 2017

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Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

29 September 2017

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Protein carbonylation, mitochondrial dysfunction, and insulin resistance

29 September 2017

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Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial

29 September 2017

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Circadian disruption leads to insulin resistance and obesity

29 September 2017

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Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance

29 September 2017

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Central leucine sensing in the control of energy homeostasis

29 September 2017

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Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

29 September 2017

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Branched-chain amino acids alter neurobehavioral function in rats

29 September 2017

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Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding.

29 September 2017

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Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

29 September 2017

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Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.

29 September 2017

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Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult rats

29 September 2017

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Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI.

29 September 2017

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29 September 2017

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The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells

29 September 2017

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Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men

29 September 2017

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Metabolic signatures of insulin resistance in 7,098 young adults

29 September 2017

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Metabolite profiling identifies pathways associated with metabolic risk in humans

29 September 2017

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Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state

29 September 2017

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Sarcopenic obesity in the elderly and strategies for weight management

29 September 2017

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A guide to analysis of mouse energy metabolism

29 September 2017

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Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet.

29 September 2017

1 reference

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Liver transplantation for classical maple syrup urine disease: long-term follow-up in 37 patients and comparative United Network for Organ Sharing experience

29 September 2017

1 reference

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New onset diabetes after transplantation (NODAT): an overview

29 September 2017

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Bidirectional association between depression and obesity in middle-aged and older women

29 September 2017

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Increased adipose protein carbonylation in human obesity

29 September 2017

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Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss

29 September 2017

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Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?

29 September 2017

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The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI.

29 September 2017

1 reference

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Disruption of mitochondrial homeostasis in organic acidurias: insights from human and animal studies

29 September 2017

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Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults

29 September 2017

1 reference

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Is protein metabolism changed with obesity?

29 September 2017

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Bromocriptine: old drug, new formulation and new indication

29 September 2017

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Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Protein metabolic roles in treatment of obesity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Impact of different long-term maintenance immunosuppressive therapy strategies on patients' outcome after heart transplantation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Signaling pathways perturbing muscle mass

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Proteomic profiling of non-obese type 2 diabetic skeletal muscle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Three targets of branched-chain amino acid supplementation in the treatment of liver disease

29 September 2017

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Classical maple syrup urine disease and brain development: principles of management and formula design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal health

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Modification of core body temperature by amino acid administration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Nutrient signaling components controlling protein synthesis in striated muscle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

The mTOR pathway in the control of protein synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Production and characterization of murine models of classic and intermediate maple syrup urine disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Potential importance of leucine in treatment of obesity and the metabolic syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Branched-chain amino acid catabolism in exercise and liver disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Branched-chain amino acids and brain function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Overview of the molecular and biochemical basis of branched-chain amino acid catabolism.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Dietary protein impact on glycemic control during weight loss

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Differential regulation of branched-chain α-ketoacid dehydrogenase kinase expression by glucocorticoids and acidification in LLC-PK1-GR101 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain alpha-keto acid dehydrogenase kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Regulation of branched-chain alpha-keto acid dehydrogenase kinase expression in rat liver

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Effects of branched-chain amino acids on protein turnover

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain alpha-keto acid dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4E availability and eIF4G phosphorylation.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Isolated isobutyryl-CoA dehydrogenase deficiency: an unrecognized defect in human valine metabolism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Correlation between amino acid induced changes in energy expenditure and protein metabolism in humans.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Inactivation of the 2-ketoglutarate and pyruvate dehydrogenase complexes of beef heart by branched chain keto acids.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Physiological covalent regulation of rat liver branched-chain alpha-ketoacid dehydrogenase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Regional amino acid transport into brain during diabetes: effect of plasma amino acids.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Glucocorticoid-mediated activation of muscle branched-chain alpha-keto acid dehydrogenase in vivo

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

In vivo inhibition of tyrosine uptake into rat retina by large neutral but not acidic amino acids.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Increased protein turnover in obese women

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Ethanol and oleate inhibition of alpha-ketoisovalerate and 3-hydroxyisobutyrate metabolism by isolated hepatocytes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Oral branched-chain amino acid granules reduce the incidence of hepatocellular carcinoma and improve event-free survival in patients with liver cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Characteristics and risk factors for hyperglycemia in Chinese female patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Plasma Amino Acid Levels and Insulin Secretion in Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Insulin suppresses atrophy- and autophagy-related genes in heart tissue and cardiomyocytes through AKT/FOXO signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Insulin and amino acids independently stimulate skeletal muscle protein synthesis in neonatal pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Morphological alterations and induction of oxidative stress in glial cells caused by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Leucine toxicity in a neuronal cell model with inhibited branched chain amino acid catabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

A novel regulatory defect in the branched-chain α-keto acid dehydrogenase complex due to a mutation in the PPM1K gene causes a mild variant phenotype of maple syrup urine disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Alpha-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Effect of a high-fat diet on 24-hour pattern of circulating adipocytokines in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Insulin increases branched-chain alpha-ketoacid dehydrogenase kinase expression in Clone 9 rat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Activity state of the branched chain alpha-ketoacid dehydrogenase complex in heart, liver, and kidney of normal, fasted, diabetic, and protein-starved rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Primary human fibroblasts from a maple syrup urine disease patient undergo apoptosis following exposure to physiological concentrations of branched chain amino acids

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Maple syrup urine disease metabolites induce apoptosis in neural cells without cytochrome c release or changes in mitochondrial membrane potential

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

An oral amino acid loading test before and after intestinal bypass operation for morbid obesity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Sex-specific differences in plasma branched-chain keto acid levels in obesity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4424797

Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms

27 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Protein, amino acids and the control of food intake

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Leucine in food mediates some of the postprandial rise in plasma leptin concentrations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Modulation of thermogenic response to parenteral amino acid infusion in surgical stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Supplementation with branched-chain amino acids attenuates hepatic apoptosis in rats with chronic liver disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

The effects of a higher protein intake during energy restriction on changes in body composition and physical function in older women

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Effect of poor diabetic control and obesity on whole body protein metabolism in man

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Insulin-dependent metabolism of branched-chain amino acids in obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Plasma amino acids and insulin levels in obesity: Response to carbohydrate intake and tryptophan supplements

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Influence of dietary deprivations on plasma concentration of free amino acids of man

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Control of late G0/G1 progression and protein modification by SmC/IGF I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Effect of Experimental Diabetes on the Levels of Aromatic and Branched-Chain Amino Acids in Rat Blood and Brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Effects of leucine on in vitro protein synthesis and degradation in rat skeletal muscles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Sirolimus therapy predisposes to new-onset diabetes mellitus after renal transplantation: a long-term analysis of various treatment regimens

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Cell biology. Rapamycin paradox resolved

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Tracer priming the bicarbonate pool

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Branched-chain 2-oxo acid dehydrogenase complex activation by tetanic contractions in rat skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

PO2-dexamethasone interactions in fibroblast growth and antioxidant enzyme activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Dietary Control and Tissue Specific Expression of Branched-Chain α-Ketoacid Dehydrogenase Kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Hepatic branched-chain alpha-keto acid dehydrogenase complex in female rats: activation by exercise and starvation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Regulation of branched-chain alpha-ketoacid dehydrogenase kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

Experimental hyperthyroidism causes inactivation of the branched-chain alpha-ketoacid dehydrogenase complex in rat liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2014.171

The contribution of protein synthesis to thermogenesis in man

31 March 2020

1 reference

12 December 2020

Effects of branched chain alpha-ketoacids on the metabolism of isolated rat liver cells. III. Interactions with pyruvate dehydrogenase

1 reference

12 December 2020

Protein synthesis is stimulated in nutritionally obese rats

1 reference

12 December 2020

Relation between obesity, insulinemia, and serum amino acid concentrations in a sample of Italian adults

1 reference

12 December 2020

Branched-chain and mixed amino acid solutions and thermogenesis in postoperative patients

1 reference

12 December 2020

Regulation of the branched chain alpha-ketoacid pathway in liver

1 reference

12 December 2020

Insulin resistance in obesity: a critical analysis at enzyme level. A review

1 reference

12 December 2020

Lysosomal pathways in hepatic protein degradation: regulatory role of amino acids

1 reference

12 December 2020

Effects of branched chain alpha-ketoacids on the metabolism of isolated rat liver cells. I. Regulation of branched chain alpha-ketoacid metabolism

1 reference

12 December 2020

Inverse alterations of BCKA dehydrogenase activity in cardiac and skeletal muscles of diabetic rats

1 reference

12 December 2020

Posttranscriptional alterations in protein masses of hepatic branched-chain keto acid dehydrogenase and its associated kinase in diabetes

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2014.171

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 June 2020

1012805361

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25287287%20AND%20SRC:MED&resulttype=core&format=json